TADA2A
Transcriptional Adaptor 2A
Gene Information Card
| Symbol | TADA2A |
|---|---|
| Full Name | Transcriptional Adaptor 2A |
| Gene Type | Protein coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 6871 ncbi.nlm.nih.gov/gene/6871 |
| Ensembl ID | ENSG00000108557 |
| UniProt ID | O75478 |
| OMIM ID | 602276 |
| HGNC ID | 11531 |
| Aliases | ADA2A, ADA2, hADA2, TADA2L |
Description
TADA2A encodes a component of the SAGA (Spt-Ada-Gcn5-acetyltransferase) and ATAC (Ada-Two-A-containing) histone acetyltransferase complexes. It functions as a transcriptional adaptor that bridges sequence-specific transcription factors to the general transcription machinery and modulates chromatin acetylation, thereby regulating gene expression. TADA2A is involved in development, cell cycle control, and DNA repair.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neurodevelopmental disorder with intellectual disability and dysmorphic features | Loss-of-function mutations in TADA2A impair SAGA complex activity, leading to aberrant gene expression during neurodevelopment | ClinVar, OMIM |
| Breast cancer | Somatic mutations and altered expression of TADA2A may disrupt transcriptional regulation of tumor suppressor genes | COSMIC, NCBI |
| Colorectal cancer | Recurrent missense mutations in TADA2A observed in tumor samples; potential role in chromatin remodeling | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.7 | Medium |
| Heart | 6.2 | Low |
| Liver | 4.1 | Low |
| Kidney | 5.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression |
| HeLa | 11.8 | Medium expression |
| K562 | 9.4 | Medium expression |
| HepG2 | 7.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | Rare | Loss of start codon; likely loss of function |
| c.487C>T (p.Arg163Trp) | Missense | 0.01% (gnomAD) | Impaired SAGA complex assembly |
| c.1024G>A (p.Glu342Lys) | Missense | Somatic (COSMIC) | Potential gain-of-function in cancer |
Mutation functional classification
Loss of Function (LOF)
Nonsense, frameshift, and start-loss variants that truncate or abolish TADA2A protein, leading to reduced SAGA complex activity.
Gain of Function (GOF)
Missense mutations in the acidic domain may enhance interaction with transcription factors, observed in some cancers.
Dominant Negative (DN)
Missense mutations in the SAGA interaction domain that disrupt complex formation while retaining partial function.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Chromatin modifying enzymes (Reactome: R-HSA-3244102)
• Transcriptional regulation by the SAGA complex (Reactome: R-HSA-3214847)
• Gene expression (Reactome: R-HSA-74160)
Protein Summary
TADA2A is a 443-amino-acid protein (UniProt O75478) containing a SANT domain and an ADA2 homology region. It interacts with GCN5 (KAT2A) and TADA3 to form the catalytic core of the SAGA complex. TADA2A stabilizes the complex and enhances histone H3 acetylation. It is ubiquitously expressed with highest levels in testis and brain. Post-translational modifications include phosphorylation and acetylation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TADA2A Knockout HEK293 Cell Line | EDJ-KQ5879 | Human | 6871 | Details Get a Quote |
| TADA2A Knockout HCT 116 Cell Line | EDJ-KQ29374 | Human | 6871 | Details Get a Quote |
| TADA2A Knockout HeLa Cell Line | EDJ-KQ29375 | Human | 6871 | Details Get a Quote |
| TADA2A Knockout A-549 Cell Line | EDJ-KQ63089 | Human | 6871 | Details Get a Quote |
