TACR2 (Tachykinin Receptor 2)
A G protein-coupled receptor for neurokinin A, involved in smooth muscle contraction, pain transmission, and neurogenic inflammation.
Gene Information Card
| Symbol | TACR2 |
|---|---|
| Full Name | Tachykinin Receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q22.1 |
| NCBI Gene ID | 6865 ncbi.nlm.nih.gov/gene/6865 |
| Ensembl ID | ENSG00000138185 |
| UniProt ID | P21452 |
| OMIM ID | 162321 |
| HGNC ID | 11526 |
| Aliases | NK2R, NKNAR, TAC2R, SKR |
Description
TACR2 encodes the tachykinin receptor 2 (NK2R), a G protein-coupled receptor that binds neurokinin A (NKA) with high affinity. Activation of NK2R stimulates phospholipase C, leading to intracellular calcium mobilization and smooth muscle contraction. The receptor is primarily expressed in peripheral tissues such as the respiratory tract, gastrointestinal tract, and urinary bladder, where it mediates bronchoconstriction, gut motility, and nociception. TACR2 is a therapeutic target for asthma, irritable bowel syndrome, and chronic pain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | NK2R activation in airway smooth muscle induces bronchoconstriction and mucus secretion. | ClinVar, OMIM |
| Irritable Bowel Syndrome (IBS) | Increased NK2R signaling in colonic smooth muscle contributes to hypermotility and visceral hypersensitivity. | NCBI Gene, PubMed |
| Chronic Pain | NK2R mediates nociceptive transmission in peripheral and central pain pathways. | OMIM, UniProt |
| Urinary Incontinence | NK2R activation in detrusor muscle promotes bladder contraction. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Smooth Muscle (airway) | 12.5 | Medium |
| Colon | 8.3 | Medium |
| Urinary Bladder | 7.1 | Medium |
| Lung | 6.8 | Medium |
| Small Intestine | 5.9 | Low |
| Stomach | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung epithelial) | 3.1 | Low expression |
| HCT116 (colon) | 2.5 | Low expression |
| HEK293 (embryonic kidney) | 0.8 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100G>A (p.Gly34Arg) | Missense | <0.01% | Likely benign; no functional data |
| c.512C>T (p.Thr171Met) | Missense | <0.01% | Unknown significance; ClinVar |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Neuroactive ligand-receptor interaction (KEGG: hsa04080)
• Calcium signaling pathway (KEGG: hsa04020)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
The tachykinin receptor 2 (NK2R) is a 398-amino acid integral membrane protein with seven transmembrane domains. It belongs to the rhodopsin-like GPCR family. Upon binding neurokinin A, NK2R couples primarily to Gq/11 proteins, activating phospholipase C and increasing intracellular calcium. The receptor is expressed in smooth muscle cells of the respiratory, gastrointestinal, and urogenital tracts, and in certain neurons. NK2R antagonists are under investigation for asthma, IBS, and pain management.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TACR2 Knockout HEK293 Cell Line | EDJ-KQ1602 | Human | 6865 | Details Get a Quote |
| TACR2 Knockout HeLa Cell Line | EDJ-KQ54605 | Human | 6865 | Details Get a Quote |
| TACR2 Knockout A-549 Cell Line | EDJ-KQ63085 | Human | 6865 | Details Get a Quote |
| TACR2 Knockout HCT 116 Cell Line | EDJ-KQ71558 | Human | 6865 | Details Get a Quote |
