TAAR5
Trace Amine Associated Receptor 5
Gene Information Card
| Symbol | TAAR5 |
|---|---|
| Full Name | Trace Amine Associated Receptor 5 |
| Gene Type | Protein coding |
| Chromosomal Location | 6q23.2 |
| NCBI Gene ID | 11248 ncbi.nlm.nih.gov/gene/11248 |
| Ensembl ID | ENSG00000135538 |
| UniProt ID | O14804 |
| OMIM ID | 606127 |
| HGNC ID | 20938 |
| Aliases | TA5, PNR, trace amine receptor 5 |
Description
TAAR5 (Trace Amine Associated Receptor 5) is a G protein-coupled receptor (GPCR) that belongs to the trace amine-associated receptor family. It is primarily expressed in the olfactory epithelium and functions as a chemosensory receptor for volatile amines, including trimethylamine. TAAR5 is involved in the detection of social and environmental odors and has been implicated in behavioral and neurological processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Altered TAAR5 expression may affect neurotransmitter modulation; genetic association studies suggest linkage to psychiatric disorders. | ClinVar, OMIM |
| Trimethylaminuria (fish odor syndrome) | TAAR5 is the primary receptor for trimethylamine; loss-of-function variants may impair odor detection but not directly cause the metabolic disorder. | UniProt, NCBI |
| Olfactory dysfunction | Variants in TAAR5 may contribute to reduced sensitivity to specific amines, affecting smell perception. | ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Olfactory mucosa | 12.5 | Medium |
| Brain (cerebellum) | 1.2 | Low |
| Testis | 0.8 | Low |
| Liver | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.1 | Low expression; used for heterologous expression studies |
| SH-SY5Y | 0.5 | Moderate expression in neuronal model |
| HepG2 | 0.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Arg79Cys | Missense | <0.01% | May alter ligand binding affinity |
| p.Leu162Phe | Missense | <0.01% | Unknown functional impact |
| p.Thr261Ile | Missense | <0.01% | Reported in ClinVar as variant of uncertain significance |
Mutation functional classification
Loss of Function (LOF)
p.Arg79Cys may reduce receptor activation by trimethylamine.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • trace-amine receptor activity |
| • amine binding | • olfactory receptor activity |
| • plasma membrane | • signal transduction |
| • detection of chemical stimulus involved in sensory perception of smell |
Pathways
• GPCR downstream signaling
• Olfactory transduction
• Trace amine signaling
Protein Summary
TAAR5 is a 342-amino acid GPCR with seven transmembrane domains. It is activated by primary amines such as trimethylamine and couples to Gαs and Gαq proteins, leading to cAMP production and calcium mobilization. The receptor is predominantly expressed in olfactory sensory neurons and plays a role in innate odor recognition. Structural studies indicate a conserved binding pocket for amine ligands.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TAAR5 Knockout HEK293 Cell Line | EDJ-KQ50839 | Human | 9038 | Details Get a Quote |
| TAAR5 Knockout HeLa Cell Line | EDJ-KQ55063 | Human | 9038 | Details Get a Quote |
| TAAR5 Knockout A-549 Cell Line | EDJ-KQ63543 | Human | 9038 | Details Get a Quote |
| TAAR5 Knockout HCT 116 Cell Line | EDJ-KQ72013 | Human | 9038 | Details Get a Quote |
