SYT15B
Synaptotagmin 15B
Gene Information Card
| Symbol | SYT15B |
|---|---|
| Full Name | synaptotagmin 15B |
| Gene Type | protein-coding |
| Chromosomal Location | 10q11.22 |
| NCBI Gene ID | 101928376 ncbi.nlm.nih.gov/gene/101928376 |
| Ensembl ID | ENSG00000204176 |
| UniProt ID | A0A0A0MTC5 |
| OMIM ID | not available |
| HGNC ID | HGNC:37247 |
| Aliases | SYT15, SYT15A, FLJ46321 |
Description
SYT15B (synaptotagmin 15B) is a protein-coding gene located on chromosome 10q11.22. It belongs to the synaptotagmin family, which is involved in calcium-dependent membrane trafficking and exocytosis. The gene is primarily expressed in the brain and testis, with limited functional characterization. No disease associations have been established in major databases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.1 | Low |
| Testis | 1.8 | Low |
| Other tissues | <1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 0.5 | Low expression |
| HEK293 | 0.3 | Low expression |
| K562 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The SYT15B protein is a member of the synaptotagmin family, characterized by two C2 domains (C2A and C2B) that mediate calcium-dependent phospholipid binding. It is predicted to play a role in vesicle trafficking and exocytosis, though its specific function remains poorly understood. Expression is low and restricted to brain and testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SYT15B Knockout HEK293 Cell Line | EDJ-KQ15588 | Human | 102724488 | Details Get a Quote |
| SYT15B Knockout A-549 Cell Line | EDJ-KQ46456 | Human | 102724488 | Details Get a Quote |
| SYT15B Knockout HCT 116 Cell Line | EDJ-KQ46457 | Human | 102724488 | Details Get a Quote |
| SYT15B Knockout HeLa Cell Line | EDJ-KQ46458 | Human | 102724488 | Details Get a Quote |
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