SYT15: Synaptotagmin 15
A member of the synaptotagmin family involved in vesicle trafficking and calcium sensing
Gene Information Card
| Symbol | SYT15 |
|---|---|
| Full Name | synaptotagmin 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q21.3 |
| NCBI Gene ID | 83849 ncbi.nlm.nih.gov/gene/83849 |
| Ensembl ID | ENSG00000120071 |
| UniProt ID | Q9BQS8 |
| OMIM ID | 610542 |
| HGNC ID | 18282 |
| Aliases | SYT15A, SYT15B, FLJ12529 |
Description
SYT15 (synaptotagmin 15) is a protein-coding gene belonging to the synaptotagmin family, which is characterized by an N-terminal transmembrane region and two C-terminal C2 domains (C2A and C2B) that mediate calcium-dependent phospholipid binding. SYT15 is involved in vesicle trafficking, exocytosis, and calcium sensing. Alternative splicing generates two isoforms: SYT15A and SYT15B.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 6.8 | Low |
| Lung | 4.2 | Low |
| Kidney | 3.1 | Low |
| Liver | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.9 | Moderate expression |
| HeLa | 5.2 | Low expression |
| K562 | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • calcium-dependent phospholipid binding | • calcium ion binding |
| • membrane trafficking | • vesicle-mediated transport |
| • synaptic vesicle exocytosis |
Pathways
• Synaptic vesicle cycle
• Calcium signaling pathway
Protein Summary
Synaptotagmin 15 is a 426-amino acid protein with a molecular weight of approximately 48 kDa. It contains a transmembrane domain and two C2 domains (C2A and C2B) that bind calcium and phospholipids. The protein is thought to regulate calcium-dependent exocytosis and vesicle fusion, particularly in neuronal and secretory cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SYT15 Knockout HEK293 Cell Line | EDJ-KQ9905 | Human | 83849 | Details Get a Quote |
| SYT15B Knockout HEK293 Cell Line | EDJ-KQ15588 | Human | 102724488 | Details Get a Quote |
| SYT15B Knockout A-549 Cell Line | EDJ-KQ46456 | Human | 102724488 | Details Get a Quote |
| SYT15B Knockout HCT 116 Cell Line | EDJ-KQ46457 | Human | 102724488 | Details Get a Quote |
| SYT15B Knockout HeLa Cell Line | EDJ-KQ46458 | Human | 102724488 | Details Get a Quote |
| SYT15 Knockout HeLa Cell Line | EDJ-KQ57482 | Human | 83849 | Details Get a Quote |
| SYT15 Knockout A-549 Cell Line | EDJ-KQ65984 | Human | 83849 | Details Get a Quote |
| SYT15 Knockout HCT 116 Cell Line | EDJ-KQ74407 | Human | 83849 | Details Get a Quote |
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