SUPT20HL1: SPT20 Homolog, SAGA Complex Component Like 1
A gene encoding a protein similar to components of the SAGA transcriptional coactivator complex, with limited functional characterization.
Gene Information Card
| Symbol | SUPT20HL1 |
|---|---|
| Full Name | SPT20 Homolog, SAGA Complex Component Like 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q21.3 |
| NCBI Gene ID | 100131731 ncbi.nlm.nih.gov/gene/100131731 |
| Ensembl ID | ENSG00000203782 |
| UniProt ID | A6NKD9 |
| OMIM ID | Not assigned |
| HGNC ID | 37287 |
| Aliases | C1orf85, FLJ39653, MGC16384 |
Description
SUPT20HL1 (SPT20 Homolog, SAGA Complex Component Like 1) is a protein-coding gene located on chromosome 1q21.3. The encoded protein shares sequence similarity with SPT20, a component of the SAGA (Spt-Ada-Gcn5-acetyltransferase) transcriptional coactivator complex. The precise biological function of SUPT20HL1 remains incompletely understood, but it is predicted to be involved in transcriptional regulation. Limited expression data suggest low to moderate expression in certain tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.3 | Low |
| Brain | 1.1 | Low |
| Lung | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low expression |
| K562 | 0.3 | Very low expression |
| HeLa | 0.4 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The SUPT20HL1 protein (UniProt A6NKD9) is 341 amino acids long and contains a SPT20 domain. It is predicted to localize to the nucleus and may participate in chromatin modification or transcription initiation. No experimental functional studies have been published.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SUPT20HL1 Knockout HEK293 Cell Line | EDJ-KQ15568 | Human | 100130302 | Details Get a Quote |
| SUPT20HL1 Knockout HeLa Cell Line | EDJ-KQ60806 | Human | 100130302 | Details Get a Quote |
| SUPT20HL1 Knockout A-549 Cell Line | EDJ-KQ69276 | Human | 100130302 | Details Get a Quote |
| SUPT20HL1 Knockout HCT 116 Cell Line | EDJ-KQ77631 | Human | 100130302 | Details Get a Quote |
