SUN2 Gene: Sad1 and UNC84 Domain Containing 2
Nuclear envelope protein involved in nuclear positioning, cell migration, and cancer progression
Gene Information Card
| Symbol | SUN2 |
|---|---|
| Full Name | Sad1 and UNC84 Domain Containing 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 22q13.1 |
| NCBI Gene ID | 25777 ncbi.nlm.nih.gov/gene/25777 |
| Ensembl ID | ENSG00000100242 |
| UniProt ID | Q9UH99 |
| OMIM ID | 613569 |
| HGNC ID | 18586 |
| Aliases | SUN2, KIAA0668, UNC84B, Sad1-unc84 domain protein 2 |
Description
SUN2 encodes a nuclear envelope protein that is a component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. It spans the inner nuclear membrane and interacts with nesprins in the perinuclear space, connecting the nuclear lamina to the cytoskeleton. SUN2 is involved in nuclear positioning, cell migration, mechanotransduction, and DNA repair. Dysregulation of SUN2 has been implicated in cancer progression, muscular dystrophies, and laminopathies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | SUN2 downregulation promotes cell migration and invasion via altered nuclear-cytoskeletal coupling | PMID: 25977310 |
| Lung adenocarcinoma | Reduced SUN2 expression correlates with poor prognosis and increased metastatic potential | PMID: 29367642 |
| Emery-Dreifuss muscular dystrophy | Mutations in SUN2 disrupt LINC complex integrity, leading to nuclear envelope instability | PMID: 24656866 |
| Hepatocellular carcinoma | SUN2 loss enhances YAP/TAZ signaling and tumor growth | PMID: 31570781 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Breast | 9.8 | Medium |
| Liver | 8.2 | Medium |
| Heart | 6.4 | Low |
| Skeletal muscle | 15.1 | High |
| Kidney | 7.3 | Low |
| Brain | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 14.2 | High expression |
| MCF7 (breast cancer) | 8.9 | Medium expression |
| HepG2 (liver cancer) | 7.5 | Medium expression |
| HeLa (cervical cancer) | 11.0 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1045C>T (p.Arg349*) | Nonsense | <0.01% | Loss of function; truncated protein |
| c.157G>A (p.Gly53Arg) | Missense | <0.01% | Unknown; predicted damaging |
| c.682_683del (p.Leu228fs) | Frameshift | <0.01% | Loss of function; premature stop |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations lead to truncated SUN2 protein, disrupting LINC complex assembly and nuclear positioning.
Gain of Function (GOF)
No gain-of-function mutations reported in SUN2.
Dominant Negative (DN)
Missense mutations in the SUN domain may act as dominant-negative by interfering with wild-type SUN2 binding to nesprins.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005635 ~ nuclear envelope | • GO:0005637 ~ nuclear inner membrane |
| • GO:0005856 ~ cytoskeleton | • GO:0006997 ~ nucleus organization |
| • GO:0030054 ~ cell junction | • GO:0031965 ~ nuclear membrane |
| • GO:0048471 ~ perinuclear region of cytoplasm | • GO:0051015 ~ actin filament binding |
| • GO:0051640 ~ organelle localization | • GO:0070588 ~ calcium ion transmembrane transport |
Pathways
• LINC complex pathway
• Nuclear envelope breakdown and reassembly
• Mechanotransduction pathway
• Cell migration and invasion pathway
Protein Summary
SUN2 is a 717-amino acid protein (UniProt Q9UH99) with an N-terminal nucleoplasmic domain, a transmembrane domain, and a C-terminal SUN domain that localizes to the perinuclear space. It forms homotrimers and interacts with nesprin-2 (SYNE2) and lamin A/C (LMNA). SUN2 is essential for tethering the nucleus to the cytoskeleton, regulating nuclear movement, and maintaining nuclear shape. Post-translational modifications include phosphorylation at Ser48 and Ser52, which modulate its interaction with partners.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NSUN2 Knockout HEK293 Cell Line | EDJ-KQ174 | Human | 54888 | Details Get a Quote |
| SUN2 Knockout HEK293 Cell Line | EDJ-KQ7525 | Human | 25777 | Details Get a Quote |
| NSUN2 Knockout A-549 Cell Line | EDJ-KQ19956 | Human | 54888 | Details Get a Quote |
| NSUN2 Knockout HCT 116 Cell Line | EDJ-KQ19957 | Human | 54888 | Details Get a Quote |
| NSUN2 Knockout HeLa Cell Line | EDJ-KQ19958 | Human | 54888 | Details Get a Quote |
| SUN2 Knockout A-549 Cell Line | EDJ-KQ34116 | Human | 25777 | Details Get a Quote |
| SUN2 Knockout HCT 116 Cell Line | EDJ-KQ34118 | Human | 25777 | Details Get a Quote |
| SUN2 Knockout HeLa Cell Line | EDJ-KQ34119 | Human | 25777 | Details Get a Quote |
| NSUN2 Knockout Hep-G2 Cell Line | EDJ-KZ378 | Human | 54888 | Details Get a Quote |
| Nsun2 Knockout TC-1 Cell Line | EDC08254 | Mouse | 28114 | Details Get a Quote |
| SUN2 Knockout HAP1 Cell Line | EDC09287 | Human | 25777 | Details Get a Quote |
Displaying Records 1 To 11 Of 11 Records
