SULT6B1: Sulfotransferase Family 6B Member 1
A cytosolic sulfotransferase involved in the metabolism of xenobiotics and endogenous compounds.
Gene Information Card
| Symbol | SULT6B1 |
|---|---|
| Full Name | Sulfotransferase Family 6B Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p22.3 |
| NCBI Gene ID | 391059 ncbi.nlm.nih.gov/gene/391059 |
| Ensembl ID | ENSG00000163002 |
| UniProt ID | Q6P3X3 |
| OMIM ID | 611697 |
| HGNC ID | 30695 |
| Aliases | SULT6B1, MGC131914 |
Description
SULT6B1 encodes a member of the sulfotransferase family, which catalyzes the sulfate conjugation of various substrates, including xenobiotics, hormones, and neurotransmitters. This gene is expressed in multiple tissues and may play a role in detoxification and hormone regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | N/A | N/A |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 3.2 | Low |
| Liver | 2.1 | Low |
| Testis | 1.8 | Low |
| Brain | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.8 | Low expression |
| HepG2 | 1.2 | Low expression |
| K562 | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • sulfotransferase activity | • transferase activity |
| • sulfate conjugation |
Pathways
• Sulfur metabolism
• Xenobiotic metabolism
Protein Summary
SULT6B1 is a 305-amino acid cytosolic sulfotransferase that catalyzes the transfer of a sulfo group from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to hydroxyl or amine groups of acceptor substrates. Its physiological substrates remain largely unknown, but it is thought to participate in the metabolism of small molecules.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SULT6B1 Knockout HEK293 Cell Line | EDJ-KQ15564 | Human | 391365 | Details Get a Quote |
| SULT6B1 Knockout HeLa Cell Line | EDJ-KQ60219 | Human | 391365 | Details Get a Quote |
| SULT6B1 Knockout A-549 Cell Line | EDJ-KQ68681 | Human | 391365 | Details Get a Quote |
| SULT6B1 Knockout HCT 116 Cell Line | EDJ-KQ77048 | Human | 391365 | Details Get a Quote |
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