SULT1C3: Sulfotransferase Family 1C Member 3
A cytosolic sulfotransferase involved in xenobiotic metabolism and hormone sulfation.
Gene Information Card
| Symbol | SULT1C3 |
|---|---|
| Full Name | Sulfotransferase Family 1C Member 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q12.1 |
| NCBI Gene ID | 442038 ncbi.nlm.nih.gov/gene/442038 |
| Ensembl ID | ENSG00000162949 |
| UniProt ID | Q6IEV9 |
| OMIM ID | 617465 |
| HGNC ID | 30689 |
| Aliases | SULT1C4, ST1C3 |
Description
SULT1C3 encodes a member of the sulfotransferase family that catalyzes the sulfate conjugation of various substrates, including hormones, neurotransmitters, and xenobiotics. This cytosolic enzyme plays a role in the detoxification of drugs and the metabolism of thyroid hormones and catecholamines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Thyroid hormone metabolism disorder | Altered sulfation of thyroid hormones may disrupt hormone homeostasis | Inferred from functional similarity to SULT1C2 (PMID: 11350115) |
| Drug-induced liver injury | Polymorphisms in SULT1C3 may affect detoxification capacity | Inferred from gene family association (ClinVar) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 2.3 | Low |
| Kidney | 1.1 | Low |
| Small intestine | 0.8 | Not detected |
| Thyroid | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 1.5 | Hepatocellular carcinoma cell line |
| HEK293 | 0.9 | Embryonic kidney cells |
| Caco-2 | 0.4 | Colorectal adenocarcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional effect (ClinVar) |
| c.100C>T | synonymous | <0.01% | No protein change (ClinVar) |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • sulfotransferase activity (GO:0008146) | • sulfation (GO:0051923) |
| • cytosol (GO:0005829) |
Pathways
• Sulfation of thyroid hormones (Reactome: R-HSA-209968)
• Phase II conjugation of xenobiotics (Reactome: R-HSA-156588)
Protein Summary
SULT1C3 is a 295-amino acid cytosolic sulfotransferase that transfers a sulfo group from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to hydroxyl or amine groups of substrates. It is expressed at low levels in liver and kidney and may contribute to the metabolism of thyroid hormones and drugs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SULT1C3 Knockout HEK293 Cell Line | EDJ-KQ15563 | Human | 442038 | Details Get a Quote |
| SULT1C3 Knockout HeLa Cell Line | EDJ-KQ60445 | Human | 442038 | Details Get a Quote |
| SULT1C3 Knockout A-549 Cell Line | EDJ-KQ68913 | Human | 442038 | Details Get a Quote |
| SULT1C3 Knockout HCT 116 Cell Line | EDJ-KQ77274 | Human | 442038 | Details Get a Quote |
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