SULT1B1
Sulfotransferase Family 1B Member 1
Gene Information Card
| Symbol | SULT1B1 |
|---|---|
| Full Name | Sulfotransferase Family 1B Member 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q13.3 |
| NCBI Gene ID | 27284 ncbi.nlm.nih.gov/gene/27284 |
| Ensembl ID | ENSG00000138684 |
| UniProt ID | O43704 |
| OMIM ID | 608436 |
| HGNC ID | 11456 |
| Aliases | ST1B2, SULT1B2 |
Description
SULT1B1 encodes a member of the sulfotransferase family that catalyzes the sulfate conjugation of various substrates, including thyroid hormones and xenobiotics. This enzyme plays a key role in hormone regulation and detoxification pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Thyroid hormone metabolism disorders | Altered sulfation of thyroid hormones may disrupt hormone homeostasis | PMID: 10642508 |
| Colorectal cancer | Polymorphisms in SULT1B1 may influence susceptibility to colorectal cancer | PMID: 15805234 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Small intestine | 8.3 | Medium |
| Colon | 6.1 | Medium |
| Kidney | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.1 | Hepatocellular carcinoma cell line |
| Caco-2 | 7.4 | Colorectal adenocarcinoma cell line |
| HEK293 | 3.8 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1042157 | missense | 0.15 (global) | Alters enzyme activity |
| rs4149455 | missense | 0.08 (global) | Reduced sulfation capacity |
Mutation functional classification
Loss of Function (LOF)
rs4149455 reduces catalytic activity toward thyroid hormones.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • sulfotransferase activity (GO:0008146) | • aryl sulfotransferase activity (GO:0050290) |
| • cytoplasm (GO:0005737) | • xenobiotic metabolic process (GO:0006805) |
Pathways
• Sulfation of thyroid hormones (Reactome: R-HSA-209968)
• Sulfation of xenobiotics (Reactome: R-HSA-156588)
Protein Summary
SULT1B1 is a 296-amino acid cytosolic sulfotransferase that transfers a sulfo group from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to hydroxyl groups of acceptor molecules. It is highly expressed in liver and gastrointestinal tissues, where it modulates thyroid hormone activity and detoxifies phenolic compounds.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SULT1B1 Knockout HEK293 Cell Line | EDJ-KQ8742 | Human | 27284 | Details Get a Quote |
| SULT1B1 Knockout HeLa Cell Line | EDJ-KQ56044 | Human | 27284 | Details Get a Quote |
| SULT1B1 Knockout A-549 Cell Line | EDJ-KQ64530 | Human | 27284 | Details Get a Quote |
| SULT1B1 Knockout HCT 116 Cell Line | EDJ-KQ72989 | Human | 27284 | Details Get a Quote |
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