SULT1A4: Sulfotransferase Family 1A Member 4
Cytosolic sulfotransferase involved in drug metabolism and hormone sulfation
Gene Information Card
| Symbol | SULT1A4 |
|---|---|
| Full Name | Sulfotransferase Family 1A Member 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 445329 ncbi.nlm.nih.gov/gene/445329 |
| Ensembl ID | ENSG00000213523 |
| UniProt ID | P50225 |
| OMIM ID | 601292 |
| HGNC ID | 11455 |
| Aliases | SULT1A2, ST1A4, HAST4 |
Description
SULT1A4 encodes a member of the sulfotransferase family, specifically the phenol sulfotransferase subfamily. This cytosolic enzyme catalyzes the sulfate conjugation of phenolic compounds, including drugs, neurotransmitters, and steroid hormones, facilitating their detoxification and elimination. SULT1A4 is highly similar to SULT1A1 but exhibits distinct substrate specificity and tissue distribution.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Altered sulfation of estrogens may influence hormone-dependent carcinogenesis | PMID: 12376485 |
| Colorectal Cancer | Polymorphisms in SULT1A4 affect metabolism of dietary carcinogens | PMID: 15642723 |
| Parkinson's Disease | Impaired sulfation of dopamine metabolites may contribute to neurodegeneration | PMID: 10944476 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Adrenal Gland | 8.3 | Medium |
| Small Intestine | 6.1 | Medium |
| Kidney | 4.2 | Low |
| Brain | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| Caco-2 | 9.5 | Colorectal adenocarcinoma cell line |
| MCF-7 | 3.2 | Breast cancer cell line |
| SH-SY5Y | 1.8 | Neuroblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.638G>A (p.Arg213His) | Missense | 0.5% in European populations | Reduced enzyme activity |
| c.688A>G (p.Asn230Asp) | Missense | 1.2% in Asian populations | Altered substrate specificity |
| c.94C>T (p.Arg32*) | Nonsense | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and missense mutations that reduce or abolish sulfotransferase activity, impairing detoxification of xenobiotics and endogenous compounds.
Gain of Function (GOF)
Not well documented; some variants may increase sulfation of certain substrates, potentially altering drug metabolism.
Dominant Negative (DN)
No evidence for dominant-negative effects in SULT1A4.
View complete mutation data：
Gene Ontology (GO)
| • sulfotransferase activity (GO:0008146) | • aryl sulfotransferase activity (GO:0050290) |
| • xenobiotic metabolic process (GO:0006805) | • sulfate conjugation (GO:0050427) |
| • cytoplasm (GO:0005737) |
Pathways
• Sulfation of hormones and neurotransmitters (Reactome: R-HSA-174362)
• Phase II drug metabolism (KEGG: hsa00982)
Protein Summary
SULT1A4 is a 295-amino acid cytosolic sulfotransferase that transfers a sulfo group from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to hydroxyl groups of phenolic substrates. It plays a key role in the metabolism of drugs, dietary compounds, and endogenous molecules such as catecholamines and thyroid hormones. The enzyme is expressed predominantly in liver, adrenal gland, and intestine, with lower levels in brain and kidney. Genetic polymorphisms in SULT1A4 can influence individual susceptibility to certain cancers and neurological disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SULT1A4 Knockout HEK293 Cell Line | EDJ-KQ15561 | Human | 445329 | Details Get a Quote |
| SULT1A4 Knockout A-549 Cell Line | EDJ-KQ46418 | Human | 445329 | Details Get a Quote |
| SULT1A4 Knockout HCT 116 Cell Line | EDJ-KQ46419 | Human | 445329 | Details Get a Quote |
| SULT1A4 Knockout HeLa Cell Line | EDJ-KQ46420 | Human | 445329 | Details Get a Quote |
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