SULT1A2
Sulfotransferase Family 1A Member 2
Gene Information Card
| Symbol | SULT1A2 |
|---|---|
| Full Name | Sulfotransferase Family 1A Member 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p12.1 |
| NCBI Gene ID | 6820 ncbi.nlm.nih.gov/gene/6820 |
| Ensembl ID | ENSG00000197165 |
| UniProt ID | P50225 |
| OMIM ID | 601292 |
| HGNC ID | 11454 |
| Aliases | ST1A2, STP2, HAST2, MGC149731 |
Description
SULT1A2 encodes a member of the sulfotransferase family that catalyzes the sulfate conjugation of various xenobiotics, drugs, and endogenous compounds. This enzyme is involved in the phase II metabolism of phenolic substrates and plays a role in the detoxification of environmental chemicals.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Altered sulfation of estrogens may influence hormone-dependent carcinogenesis | PMID: 12354769 |
| Colorectal Cancer | Polymorphisms in SULT1A2 affect metabolism of dietary carcinogens | PMID: 14559847 |
| Liver Disease | Reduced expression linked to impaired detoxification | PMID: 15640458 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Adrenal Gland | 8.3 | Medium |
| Kidney | 6.1 | Low |
| Small Intestine | 4.7 | Low |
| Colon | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| Caco-2 | 7.8 | Colorectal adenocarcinoma cell line |
| HEK293 | 2.1 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1059491 (Ile7Thr) | missense | 0.15 (global) | Altered substrate specificity |
| rs1079738 (Asn235Thr) | missense | 0.08 (global) | Reduced enzyme activity |
| rs4149299 (Arg37His) | missense | 0.02 (global) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
rs1079738 (Asn235Thr) associated with reduced sulfation activity in vitro.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • sulfotransferase activity (GO:0008146) | • 3'-phosphoadenosine 5'-phosphosulfate binding (GO:0050427) |
| • xenobiotic metabolic process (GO:0006805) | • cytoplasm (GO:0005737) |
Pathways
• Sulfation of xenobiotics (Reactome: R-HSA-156588)
• Phase II conjugation (KEGG: map00980)
Protein Summary
SULT1A2 is a cytosolic sulfotransferase that transfers a sulfo group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to hydroxyl or amine groups of substrates. It is primarily expressed in liver and adrenal gland, and participates in the metabolism of drugs, hormones, and dietary compounds. Polymorphisms in this gene can alter enzyme activity and influence susceptibility to certain cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SULT1A2 Knockout HEK293 Cell Line | EDJ-KQ5859 | Human | 6799 | Details Get a Quote |
| SULT1A2 Knockout HeLa Cell Line | EDJ-KQ29337 | Human | 6799 | Details Get a Quote |
| SULT1A2 Knockout A-549 Cell Line | EDJ-KQ63070 | Human | 6799 | Details Get a Quote |
| SULT1A2 Knockout HCT 116 Cell Line | EDJ-KQ71546 | Human | 6799 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
