STYXL2
Serine/Threonine/Tyrosine Interacting Like 2
Gene Information Card
| Symbol | STYXL2 |
|---|---|
| Full Name | Serine/Threonine/Tyrosine Interacting Like 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q24.3 |
| NCBI Gene ID | 54976 ncbi.nlm.nih.gov/gene/54976 |
| Ensembl ID | ENSG00000117569 |
| UniProt ID | Q9H2H9 |
| OMIM ID | 615145 |
| HGNC ID | 30755 |
| Aliases | MK-STYX, STYX2, DKFZp686B20107 |
Description
STYXL2 (Serine/Threonine/Tyrosine Interacting Like 2) encodes a member of the dual-specificity pseudophosphatase family. The protein contains a catalytically inactive phosphatase domain and is thought to regulate signaling pathways by competing with active phosphatases. It is also known as MK-STYX (MAPK pseudophosphatase).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Ovarian cancer | Potential role in cell proliferation and migration; altered expression observed | COSMIC |
| Breast cancer | Upregulated in some subtypes; may influence tumor progression | COSMIC |
| Colorectal cancer | Expression changes noted; functional role unclear | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.2 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.2 | Embryonic kidney |
| HeLa | 7.8 | Cervical cancer |
| MCF7 | 9.1 | Breast cancer |
| A549 | 6.5 | Lung cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | missense | <0.01% | Unknown |
| c.205G>A (p.Gly69Arg) | missense | <0.01% | Unknown |
| c.412A>G (p.Ile138Val) | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity (inactive) | • phosphatase activity |
| • cytoplasm | • nucleus |
Pathways
• MAPK signaling pathway (putative regulator)
Protein Summary
STYXL2 encodes a 340-amino acid protein (UniProt Q9H2H9) with a pseudophosphatase domain. It lacks catalytic activity due to substitution of the essential cysteine residue. The protein localizes to the cytoplasm and nucleus and may modulate MAPK signaling by interacting with active phosphatases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STYXL2 Knockout HEK293 Cell Line | EDJ-KQ104 | Human | 92235 | Details Get a Quote |
| STYXL2 Knockout HeLa Cell Line | EDJ-KQ57829 | Human | 92235 | Details Get a Quote |
| STYXL2 Knockout A-549 Cell Line | EDJ-KQ66328 | Human | 92235 | Details Get a Quote |
| STYXL2 Knockout HCT 116 Cell Line | EDJ-KQ74752 | Human | 92235 | Details Get a Quote |
