STYXL1
Serine/Threonine/Tyrosine Interacting Like 1
Gene Information Card
| Symbol | STYXL1 |
|---|---|
| Full Name | Serine/Threonine/Tyrosine Interacting Like 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q11.23 |
| NCBI Gene ID | 51657 ncbi.nlm.nih.gov/gene/51657 |
| Ensembl ID | ENSG00000106348 |
| UniProt ID | Q9H0A9 |
| OMIM ID | 615158 |
| HGNC ID | 30663 |
| Aliases | MK-STYX, DUSP24, STYX1 |
Description
STYXL1 (also known as MK-STYX) is a member of the dual-specificity phosphatase (DUSP) family but lacks catalytic phosphatase activity due to a critical active-site mutation, classifying it as a pseudophosphatase. It is involved in regulating stress granule dynamics, cell migration, and apoptosis. STYXL1 is expressed in multiple tissues and has been implicated in cancer progression and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression of STYXL1 affects cell migration and stress granule formation, promoting tumorigenesis | PMID: 25645922 |
| Neurodevelopmental disorders | STYXL1 interacts with signaling pathways involved in neuronal development | PMID: 30377383 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.5 | Moderate expression |
| HeLa | 8.9 | Moderate expression |
| A549 | 7.2 | Low expression |
| MCF7 | 6.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Potential loss of start codon, likely loss of function |
| c.100C>T (p.Arg34Trp) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity (inactive) | • protein binding |
| • cytoplasm | • stress granule |
| • nucleus |
Pathways
• MAPK signaling pathway
• Stress granule assembly
Protein Summary
STYXL1 encodes a 352-amino acid protein (MK-STYX) that contains a dual-specificity phosphatase domain but lacks catalytic activity due to substitution of the essential cysteine residue. It functions as a scaffold or regulator in signaling pathways, particularly influencing stress granule dynamics and cell motility. The protein is predominantly cytoplasmic and shuttles to stress granules under cellular stress.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STYXL1 Knockout HEK293 Cell Line | EDJ-KQ250 | Human | 51657 | Details Get a Quote |
| STYXL1 Knockout HCT 116 Cell Line | EDJ-KQ39213 | Human | 51657 | Details Get a Quote |
| STYXL1 Knockout HeLa Cell Line | EDJ-KQ18274 | Human | 51657 | Details Get a Quote |
| STYXL1 Knockout A-549 Cell Line | EDJ-KQ37889 | Human | 51657 | Details Get a Quote |
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