STYX: Serine/Threonine/Tyrosine Interacting Protein
A pseudophosphatase involved in spermatogenesis and cellular signaling
Gene Information Card
| Symbol | STYX |
|---|---|
| Full Name | Serine/Threonine/Tyrosine Interacting Protein |
| Gene Type | Protein coding |
| Chromosomal Location | Xq13.1 |
| NCBI Gene ID | 6815 ncbi.nlm.nih.gov/gene/6815 |
| Ensembl ID | ENSG00000198796 |
| UniProt ID | Q9Y6J8 |
| OMIM ID | 300034 |
| HGNC ID | 11462 |
| Aliases | STYX1, STYX2 |
Description
STYX (Serine/Threonine/Tyrosine Interacting Protein) is a protein-coding gene located on the X chromosome. It encodes a pseudophosphatase that lacks catalytic phosphatase activity due to a critical mutation in the active site. STYX is involved in spermatogenesis, particularly in the regulation of germ cell development and apoptosis. It interacts with phosphorylated proteins and may modulate signaling pathways by competing with active phosphatases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility (spermatogenic failure) | STYX pseudophosphatase may disrupt germ cell apoptosis and differentiation | Limited evidence from animal models; human studies ongoing |
| Cancer (potential role) | Altered STYX expression may affect cell survival signaling | Preliminary expression data in COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 2.1 | Low |
| Heart | 1.0 | Low |
| Liver | 0.8 | Low |
| Kidney | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 3.2 | Low expression |
| HeLa | 2.8 | Low expression |
| K562 | 1.5 | Low expression |
| MCF7 | 2.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely affects translation initiation |
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations documented.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • protein tyrosine phosphatase activity (GO:0004725) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) | • spermatogenesis (GO:0007283) |
| • dephosphorylation (GO:0016311) |
Pathways
• REACT:111045 - Developmental Biology
• REACT:116909 - Signaling by Receptor Tyrosine Kinases
Protein Summary
The STYX protein is a 340-amino acid pseudophosphatase that contains a catalytically inactive phosphatase domain. It localizes to the nucleus and cytoplasm and is highly expressed in testis. STYX binds to phosphoserine/threonine/tyrosine residues and may function as a competitive inhibitor of active phosphatases, thereby modulating signaling cascades involved in germ cell development and apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STYXL2 Knockout HEK293 Cell Line | EDJ-KQ104 | Human | 92235 | Details Get a Quote |
| STYX Knockout HEK293 Cell Line | EDJ-KQ249 | Human | 6815 | Details Get a Quote |
| STYXL1 Knockout HEK293 Cell Line | EDJ-KQ250 | Human | 51657 | Details Get a Quote |
| STYX Knockout A-549 Cell Line | EDJ-KQ28076 | Human | 6815 | Details Get a Quote |
| STYXL1 Knockout HCT 116 Cell Line | EDJ-KQ39213 | Human | 51657 | Details Get a Quote |
| STYX Knockout HeLa Cell Line | EDJ-KQ18273 | Human | 6815 | Details Get a Quote |
| STYXL1 Knockout HeLa Cell Line | EDJ-KQ18274 | Human | 51657 | Details Get a Quote |
| STYX Knockout HCT 116 Cell Line | EDJ-KQ29347 | Human | 6815 | Details Get a Quote |
| STYXL1 Knockout A-549 Cell Line | EDJ-KQ37889 | Human | 51657 | Details Get a Quote |
| STYXL2 Knockout HeLa Cell Line | EDJ-KQ57829 | Human | 92235 | Details Get a Quote |
| STYXL2 Knockout A-549 Cell Line | EDJ-KQ66328 | Human | 92235 | Details Get a Quote |
| STYXL2 Knockout HCT 116 Cell Line | EDJ-KQ74752 | Human | 92235 | Details Get a Quote |
