STYK1: Serine/Threonine/Tyrosine Kinase 1
A pseudokinase with potential roles in cancer and development
Gene Information Card
| Symbol | STYK1 |
|---|---|
| Full Name | serine/threonine/tyrosine kinase 1 |
| Gene Type | protein coding (pseudokinase) |
| Chromosomal Location | 12p13.1 |
| NCBI Gene ID | 55359 ncbi.nlm.nih.gov/gene/55359 |
| Ensembl ID | ENSG00000111247 |
| UniProt ID | Q6P3W7 |
| OMIM ID | 611433 |
| HGNC ID | 29190 |
| Aliases | SuRTK106, NOK, STYK1 |
Description
STYK1 (serine/threonine/tyrosine kinase 1) is a protein-coding gene located on chromosome 12p13.1. It encodes a putative receptor tyrosine kinase-like protein that lacks catalytic activity (pseudokinase). STYK1 is implicated in cell proliferation, migration, and survival, and is overexpressed in several cancers including breast, lung, and ovarian cancer. Its exact physiological function remains under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell proliferation and invasion | PMID: 21750547 |
| Lung cancer | Upregulation associated with poor prognosis | PMID: 22952447 |
| Ovarian cancer | Enhanced tumor growth via MAPK/ERK pathway | PMID: 23327944 |
| Hepatocellular carcinoma | Promotes metastasis through EMT | PMID: 25633841 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Kidney | 5.1 | Low |
| Liver | 3.4 | Low |
| Lung | 2.9 | Low |
| Breast | 1.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 12.5 | Overexpressed |
| A549 (lung cancer) | 9.8 | Overexpressed |
| HepG2 (liver cancer) | 7.3 | Moderate |
| HEK293 (embryonic kidney) | 4.2 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.02% (gnomAD) | Unknown functional impact |
| c.457G>A (p.Gly153Arg) | Missense | 0.01% (gnomAD) | Predicted damaging (SIFT) |
| c.832C>T (p.Arg278Trp) | Missense | 0.005% (gnomAD) | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function role.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • protein kinase activity (GO:0004672) | • ATP binding (GO:0005524) |
| • protein phosphorylation (GO:0006468) | • phosphorylation (GO:0016310) |
| • signal transduction (GO:0007165) |
Pathways
• MAPK signaling pathway (KEGG: hsa04010)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• Focal adhesion (KEGG: hsa04510)
Protein Summary
STYK1 encodes a 422-amino acid protein with a single transmembrane domain and a kinase-like domain that lacks catalytic activity (pseudokinase). It localizes to the plasma membrane and may function as a scaffold or adaptor in signaling pathways. Overexpression in multiple cancers suggests a role in tumorigenesis, though its precise molecular mechanism remains unclear.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STYK1 Knockout HEK293 Cell Line | EDJ-KQ12064 | Human | 55359 | Details Get a Quote |
| STYK1 Knockout HCT 116 Cell Line | EDJ-KQ40709 | Human | 55359 | Details Get a Quote |
| STYK1 Knockout HeLa Cell Line | EDJ-KQ40710 | Human | 55359 | Details Get a Quote |
| STYK1 Knockout A-549 Cell Line | EDJ-KQ65079 | Human | 55359 | Details Get a Quote |
