STX19 Gene (Syntaxin 19): Function, Expression, and Disease Links | Biomedical Database

STX19 (Syntaxin 19) is a protein-coding gene located on chromosome 3q11.1. It encodes a member of the syntaxin family of SNARE proteins, which are essential for intracellular membrane fusion and vesicle trafficking. STX19 is predicted to be involved in vesicle-mediated transport, particularly in the Golgi apparatus and endosomal compartments. The protein contains a conserved SNARE domain and a C-terminal transmembrane region. STX19 is expressed in various tissues, with notable levels in the gastrointestinal tract and endocrine tissues. Its precise physiological roles and disease associations are still under investigation, but it may contribute to cellular processes such as exocytosis and membrane organization.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• SNARE interactions in vesicular transport (KEGG: hsa04130)

• Membrane trafficking (Reactome: R-HSA-199991)

STX19 is a 299-amino-acid protein with a molecular weight of approximately 33 kDa. It belongs to the syntaxin family, characterized by a C-terminal transmembrane domain and a cytoplasmic SNARE domain that mediates interactions with other SNARE proteins to drive membrane fusion. STX19 is localized to the Golgi and endosomal membranes, suggesting a role in intracellular trafficking. Its expression is enriched in epithelial tissues, particularly the gastrointestinal tract. Structural predictions indicate a typical syntaxin fold with a longin domain. Functional studies are limited, but STX19 may participate in regulated secretion or endosomal sorting.