STX10: Syntaxin 10 Gene
A member of the syntaxin family involved in intracellular vesicle trafficking and Golgi transport
Gene Information Card
| Symbol | STX10 |
|---|---|
| Full Name | Syntaxin 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 8677 ncbi.nlm.nih.gov/gene/8677 |
| Ensembl ID | ENSG00000104872 |
| UniProt ID | O60499 |
| OMIM ID | 618639 |
| HGNC ID | 11442 |
| Aliases | Syn10, STX10A, STX10B |
Description
STX10 (Syntaxin 10) is a protein-coding gene that encodes a member of the syntaxin family of SNARE proteins. Syntaxin 10 is primarily localized to the Golgi apparatus and is involved in vesicle docking and fusion, particularly in retrograde transport from endosomes to the Golgi. It plays a critical role in maintaining Golgi structure and function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Congenital disorder of glycosylation (CDG) | Impaired Golgi trafficking due to STX10 dysfunction may disrupt glycosylation pathways | Limited; inferred from functional studies and rare variants in ClinVar |
| Cancer (pancreatic, breast) | Altered STX10 expression may affect tumor cell invasion and vesicle-mediated signaling | Expression data from COSMIC; mechanistic studies ongoing |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Pancreas | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.0 | Cervical cancer cell line |
| HEK293 | 11.5 | Embryonic kidney cells |
| MCF7 | 9.8 | Breast cancer cell line |
| HepG2 | 7.2 | Liver cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; functional impact unknown |
| c.287C>T (p.Pro96Leu) | Missense | <0.01% | Rare variant; predicted benign by in silico tools |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may reduce protein stability or SNARE complex formation, but no confirmed loss-of-function alleles reported.
Gain of Function (GOF)
No evidence of gain-of-function mutations.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • ER to Golgi vesicle-mediated transport (GO:0006888) | • vesicle-mediated transport (GO:0016192) |
| • SNAP receptor activity (GO:0005484) | • Golgi apparatus (GO:0005794) |
| • SNARE complex (GO:0031201) |
Pathways
• SNARE interactions in vesicular transport (KEGG: hsa04130)
• Golgi-to-ER retrograde transport (Reactome: R-HSA-6811442)
Protein Summary
Syntaxin 10 is a 287-amino acid protein with a C-terminal transmembrane domain and a SNARE motif. It localizes to the Golgi and forms a SNARE complex with SNAP29 and VAMP4 to mediate endosome-to-Golgi trafficking. It is ubiquitously expressed with highest levels in brain and testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STX10 Knockout HEK293 Cell Line | EDJ-KQ2566 | Human | 8677 | Details Get a Quote |
| STX10 Knockout A-549 Cell Line | EDJ-KQ23237 | Human | 8677 | Details Get a Quote |
| STX10 Knockout HCT 116 Cell Line | EDJ-KQ23238 | Human | 8677 | Details Get a Quote |
| STX10 Knockout HeLa Cell Line | EDJ-KQ23239 | Human | 8677 | Details Get a Quote |
