STRAP (Serine/Threonine Kinase Receptor Associated Protein)
A multifunctional adaptor protein involved in TGF-β signaling, RNA processing, and cellular stress responses.
Gene Information Card
| Symbol | STRAP |
|---|---|
| Full Name | Serine/Threonine Kinase Receptor Associated Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 12p12.3 |
| NCBI Gene ID | 11171 ncbi.nlm.nih.gov/gene/11171 |
| Ensembl ID | ENSG00000111247 |
| UniProt ID | Q9Y3F4 |
| OMIM ID | 606067 |
| HGNC ID | 11397 |
| Aliases | UNRIP, MAWD |
Description
STRAP (Serine/Threonine Kinase Receptor Associated Protein) encodes a WD40 repeat-containing protein that functions as an adaptor in TGF-β signaling by interacting with type I and type II receptors. It also participates in RNA processing via association with the UNR (upstream of N-ras) protein and modulates cellular stress responses. STRAP is implicated in various cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Overexpression of STRAP enhances TGF-β signaling and promotes tumor growth. | NCBI Gene, COSMIC |
| Colorectal cancer | STRAP upregulation correlates with poor prognosis and increased cell proliferation. | NCBI Gene, COSMIC |
| Breast cancer | STRAP overexpression linked to metastasis and resistance to apoptosis. | NCBI Gene, COSMIC |
| Gastric cancer | STRAP overexpression associated with advanced tumor stage and lymph node metastasis. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 25.4 | Medium |
| Colon | 20.1 | Medium |
| Breast | 18.7 | Medium |
| Stomach | 22.3 | Medium |
| Liver | 15.6 | Low |
| Kidney | 12.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung) | 30.2 | High expression |
| HCT116 (colon) | 28.5 | High expression |
| MCF7 (breast) | 26.1 | High expression |
| HeLa (cervical) | 24.8 | Medium expression |
| HEK293 (embryonic kidney) | 19.3 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Potential loss of start codon; functional impact unknown. |
| c.100G>A (p.Glu34Lys) | Missense | <0.1% | Substitution in WD40 domain; uncertain significance. |
| c.200C>T (p.Pro67Leu) | Missense | <0.1% | Rare variant; no known disease association. |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in STRAP. Knockdown studies in cell lines show reduced TGF-β signaling and proliferation.
Gain of Function (GOF)
Overexpression of wild-type STRAP is observed in multiple cancers, suggesting a gain-of-function role in tumorigenesis.
Dominant Negative (DN)
No dominant-negative mutations have been described for STRAP.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TGF-beta signaling pathway (KEGG hsa04350)
• SMAD2/SMAD3:SMAD4 heterotrimer regulation
• mRNA splicing via UNR complex
Protein Summary
STRAP is a 41 kDa protein containing seven WD40 repeats that form a beta-propeller structure. It interacts with TGF-β receptors (TβRI and TβRII) to facilitate SMAD2/3 phosphorylation and nuclear translocation. Additionally, STRAP binds UNR to regulate mRNA stability and translation. Its overexpression in cancers suggests a role in promoting cell survival and proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STRAP Knockout HEK293 Cell Line | EDJ-KQ51050 | Human | 11171 | Details Get a Quote |
| STRAP Knockout HeLa Cell Line | EDJ-KQ55592 | Human | 11171 | Details Get a Quote |
| STRAP Knockout A-549 Cell Line | EDJ-KQ64087 | Human | 11171 | Details Get a Quote |
| STRAP Knockout HCT 116 Cell Line | EDJ-KQ72538 | Human | 11171 | Details Get a Quote |
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