STRA8: Stimulated by Retinoic Acid 8
Key regulator of meiotic initiation in germ cells
Gene Information Card
| Symbol | STRA8 |
|---|---|
| Full Name | Stimulated by Retinoic Acid 8 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q33 |
| NCBI Gene ID | 64293 ncbi.nlm.nih.gov/gene/64293 |
| Ensembl ID | ENSG00000146856 |
| UniProt ID | Q7Z7C8 |
| OMIM ID | 609987 |
| HGNC ID | 30644 |
| Aliases | STRA8, stimulated by retinoic acid 8 |
Description
STRA8 (Stimulated by Retinoic Acid 8) is a protein-coding gene that plays a critical role in the initiation of meiosis in germ cells. It is directly induced by retinoic acid and is essential for spermatogenesis and oogenesis. STRA8 expression is restricted to premeiotic germ cells in the testis and ovary, and its function is required for the transition from mitotic to meiotic cell cycle.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Non-obstructive azoospermia | Loss of STRA8 function disrupts meiotic initiation in spermatocytes, leading to impaired spermatogenesis | ClinVar: pathogenic variants in STRA8 associated with male infertility |
| Premature ovarian failure | Defects in STRA8 impair meiotic entry in oocytes, contributing to ovarian dysfunction | OMIM: 609987; case reports of STRA8 mutations in women with primary ovarian insufficiency |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | High |
| Ovary | 3.2 | Low |
| Fallopian tube | 0.8 | Not detected |
| Endometrium | 0.5 | Not detected |
| Prostate | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Spermatogonia | 45.0 | High expression; key for meiotic initiation |
| Primary spermatocytes | 30.0 | Expressed during early meiosis |
| Oogonia | 20.0 | Expressed in fetal ovary |
| HEK293 | 0.1 | Not expressed; non-germline cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | Rare | Loss of start codon; likely loss of function |
| c.295C>T (p.Arg99*) | Nonsense | Rare | Premature stop; loss of function |
| c.464_465del (p.Leu155fs) | Frameshift | Rare | Frameshift; loss of function |
Mutation functional classification
Loss of Function (LOF)
STRA8 loss-of-function mutations impair meiotic initiation, leading to infertility in both males and females.
Gain of Function (GOF)
No gain-of-function mutations reported for STRA8.
Dominant Negative (DN)
No dominant-negative mutations reported for STRA8.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Retinoic acid signaling pathway
• Meiotic cell cycle
Protein Summary
The STRA8 protein is a nuclear and cytoplasmic protein that acts as a key regulator of meiotic initiation. It is induced by retinoic acid and is essential for the transition from mitotic to meiotic cell cycle in germ cells. The protein contains a conserved domain of unknown function (DUF) and is involved in transcriptional regulation. STRA8 is primarily expressed in premeiotic germ cells of the testis and ovary.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STRA8 Knockout HEK293 Cell Line | EDJ-KQ15551 | Human | 346673 | Details Get a Quote |
| STRA8 Knockout HeLa Cell Line | EDJ-KQ59805 | Human | 346673 | Details Get a Quote |
| STRA8 Knockout A-549 Cell Line | EDJ-KQ68273 | Human | 346673 | Details Get a Quote |
| STRA8 Knockout HCT 116 Cell Line | EDJ-KQ76648 | Human | 346673 | Details Get a Quote |
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