STOML2 Gene - Stomatin Like Protein 2 | Function, Disease & Expression

STOML2 (stomatin like 2) encodes a member of the stomatin family of integral membrane proteins. The protein localizes to the inner mitochondrial membrane and is involved in mitochondrial biogenesis, lipid metabolism, and the regulation of mitochondrial membrane potential. It plays a role in cell proliferation, apoptosis, and has been implicated in various cancers, including breast, lung, and colorectal cancer. STOML2 interacts with cardiolipin and other mitochondrial proteins to support cristae organization and respiratory chain assembly.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Mitochondrial biogenesis (Reactome: R-HSA-1592230)

• Respiratory electron transport (Reactome: R-HSA-611105)

• Cardiolipin biosynthesis (Reactome: R-HSA-1483196)

• PI3K/Akt signaling (KEGG: hsa04151)

STOML2 is a 356-amino acid protein (UniProt Q9UJZ1) with a molecular weight of approximately 38.5 kDa. It contains a stomatin-like domain and a transmembrane region that anchors it to the inner mitochondrial membrane. The protein forms oligomers and interacts with cardiolipin to stabilize mitochondrial cristae. It also binds to subunits of the respiratory chain complexes, facilitating their assembly and activity. STOML2 is widely expressed in metabolically active tissues such as heart and skeletal muscle, and its overexpression in cancers suggests a role in promoting cell survival and proliferation.