STMP1: Short Transmembrane Mitochondrial Protein 1
A mitochondrial protein involved in apoptosis and cancer biology
Gene Information Card
| Symbol | STMP1 |
|---|---|
| Full Name | Short Transmembrane Mitochondrial Protein 1 |
| Gene Type | Protein-coding |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 100506334 ncbi.nlm.nih.gov/gene/100506334 |
| Ensembl ID | ENSG00000205744 |
| UniProt ID | A6NKD2 |
| OMIM ID | 618738 |
| HGNC ID | 44277 |
| Aliases | MGC16384, C7orf49 |
Description
STMP1 (Short Transmembrane Mitochondrial Protein 1) is a protein-coding gene located on chromosome 7q22.1. The encoded protein is a small transmembrane protein localized to mitochondria, where it plays a role in mitochondrial dynamics and apoptosis. STMP1 is involved in the regulation of cell death and has been implicated in various cancers, including breast and colorectal cancer. Its expression is associated with poor prognosis in certain tumor types.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | STMP1 overexpression promotes mitochondrial fragmentation and apoptosis resistance, contributing to tumor progression. | PMID: 31570799 |
| Colorectal cancer | STMP1 upregulation correlates with advanced stage and metastasis, possibly via mitochondrial dysfunction. | PMID: 32015517 |
| Hepatocellular carcinoma | STMP1 expression is elevated in liver cancer tissues and linked to reduced survival. | PMID: 32697934 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Breast | 8.2 | Low |
| Colon | 6.1 | Low |
| Liver | 4.8 | Low |
| Lung | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.3 | High expression |
| HCT116 (colorectal cancer) | 11.7 | Moderate expression |
| HepG2 (liver cancer) | 9.4 | Moderate expression |
| A549 (lung cancer) | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown effect |
| c.55C>T | Synonymous | <0.01% | No protein change |
| c.101G>A | Missense | <0.01% | Unknown effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in STMP1.
Gain of Function (GOF)
Overexpression in cancer suggests potential gain-of-function role in apoptosis resistance.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • mitochondrion (GO:0005739) | • integral component of membrane (GO:0016021) |
| • apoptotic process (GO:0006915) | • positive regulation of apoptotic process (GO:0043065) |
| • mitochondrion organization (GO:0007005) |
Pathways
• Apoptosis (KEGG hsa04210)
• Mitochondrial dynamics (Reactome R-HSA-169911)
Protein Summary
STMP1 encodes a 68-amino acid short transmembrane protein localized to the mitochondrial outer membrane. It contains a single transmembrane domain and a short C-terminal tail. The protein is involved in mitochondrial fragmentation and apoptosis regulation. Overexpression of STMP1 sensitizes cells to apoptotic stimuli, while its knockdown reduces apoptosis. STMP1 interacts with mitochondrial fission proteins and modulates cristae structure. Its expression is upregulated in several cancers and correlates with poor prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STMP1 Knockout HEK293 Cell Line | EDJ-KQ15544 | Human | 647087 | Details Get a Quote |
| STMP1 Knockout A-549 Cell Line | EDJ-KQ46391 | Human | 647087 | Details Get a Quote |
| STMP1 Knockout HCT 116 Cell Line | EDJ-KQ46392 | Human | 647087 | Details Get a Quote |
| STMP1 Knockout HeLa Cell Line | EDJ-KQ46393 | Human | 647087 | Details Get a Quote |
