STMN4: Stathmin 4 - A Regulator of Microtubule Dynamics
Comprehensive genomic and proteomic analysis of STMN4, a neuron-enriched phosphoprotein involved in cytoskeletal regulation and cancer.
Gene Information Card
| Symbol | STMN4 |
|---|---|
| Full Name | Stathmin 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 8p21.2 |
| NCBI Gene ID | 81551 ncbi.nlm.nih.gov/gene/81551 |
| Ensembl ID | ENSG00000104419 |
| UniProt ID | Q9H169 |
| OMIM ID | 610381 |
| HGNC ID | 17056 |
| Aliases | RB3, stathmin-like 4 |
Description
STMN4 (stathmin 4) encodes a member of the stathmin family of microtubule-destabilizing phosphoproteins. The protein, also known as RB3, regulates microtubule dynamics by sequestering tubulin heterodimers and promoting catastrophe. STMN4 is predominantly expressed in the nervous system and plays roles in neuronal differentiation, axon guidance, and synaptic plasticity. Its expression is altered in various cancers and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of STMN4 promotes cell proliferation and migration via microtubule destabilization and enhanced mitotic spindle dynamics. | PMID: 25605274 |
| Lung adenocarcinoma | Upregulation of STMN4 correlates with poor prognosis and increased metastatic potential through regulation of epithelial-mesenchymal transition. | PMID: 29367642 |
| Neuroblastoma | STMN4 is highly expressed in aggressive neuroblastoma subtypes and contributes to chemoresistance by modulating microtubule stability. | PMID: 23575477 |
| Alzheimer's disease | Altered STMN4 expression in hippocampal neurons may affect synaptic integrity and microtubule-associated transport. | PMID: 20628086 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 48.2 | High |
| Spinal cord | 32.1 | Medium |
| Adrenal gland | 15.8 | Medium |
| Testis | 8.4 | Low |
| Lung | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 62.5 | Neuronal model; high endogenous expression |
| U-87 MG (glioblastoma) | 45.3 | Glial tumor line; moderate expression |
| MCF7 (breast cancer) | 12.7 | Low expression; upregulated in aggressive subtypes |
| A549 (lung cancer) | 8.9 | Low baseline; induced under stress |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.197C>T (p.Pro66Leu) | Missense | <0.01% | Unknown; predicted benign by SIFT |
| c.304G>A (p.Glu102Lys) | Missense | <0.01% | Unknown; predicted possibly damaging by PolyPhen |
| c.421_423del (p.Lys141del) | In-frame deletion | <0.01% | Unknown; may affect tubulin binding |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in STMN4.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function via increased microtubule destabilization.
Dominant Negative (DN)
No dominant-negative mutations characterized.
View complete mutation data：
Gene Ontology (GO)
Pathways
• KEGG: hsa04540 - Gap junction
• KEGG: hsa04810 - Regulation of actin cytoskeleton
• Reactome: R-HSA-380284 - Loss of proteins required for interphase microtubule organization from the centrosome
• Reactome: R-HSA-8854518 - Formation of tubulin folding intermediates by CCT/TriC
Protein Summary
STMN4 (stathmin 4) is a 150-amino acid protein (UniProt Q9H169) belonging to the stathmin family. It contains a conserved stathmin-like domain that mediates tubulin binding and microtubule destabilization. The protein is regulated by phosphorylation at multiple serine residues (e.g., Ser16, Ser63) by kinases such as CDK1 and PKA, which modulate its activity during the cell cycle and neuronal differentiation. STMN4 is predominantly cytoplasmic and enriched in growth cones and synaptic regions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STMN4 Knockout HEK293 Cell Line | EDJ-KQ3272 | Human | 81551 | Details Get a Quote |
| STMN4 Knockout HeLa Cell Line | EDJ-KQ57392 | Human | 81551 | Details Get a Quote |
| STMN4 Knockout A-549 Cell Line | EDJ-KQ65899 | Human | 81551 | Details Get a Quote |
| STMN4 Knockout HCT 116 Cell Line | EDJ-KQ74325 | Human | 81551 | Details Get a Quote |
