STMN3: Stathmin 3 - A Regulator of Microtubule Dynamics
Comprehensive gene overview of STMN3, including function, expression, and disease associations.
Gene Information Card
| Symbol | STMN3 |
|---|---|
| Full Name | stathmin 3 |
| Gene Type | protein coding |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | 50861 ncbi.nlm.nih.gov/gene/50861 |
| Ensembl ID | ENSG00000101204 |
| UniProt ID | Q9NZ72 |
| OMIM ID | 609972 |
| HGNC ID | 11386 |
| Aliases | SCLIP, stathmin-like 3 |
Description
STMN3 (stathmin 3) is a protein-coding gene that belongs to the stathmin family of microtubule-destabilizing proteins. It regulates microtubule dynamics by sequestering tubulin dimers and promoting microtubule catastrophe. STMN3 is highly expressed in the nervous system and is involved in neuronal development, synaptic plasticity, and cell cycle progression. Dysregulation of STMN3 has been implicated in various cancers and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression leads to increased microtubule dynamics, promoting cell proliferation and migration. | COSMIC, PubMed |
| Alzheimer's disease | Altered expression may affect tau phosphorylation and microtubule stability. | PubMed |
| Schizophrenia | Genetic variants associated with altered STMN3 expression in brain regions. | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 35.2 | High |
| Testis | 12.8 | Medium |
| Lung | 5.1 | Low |
| Liver | 2.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 28.5 | Neuronal model |
| HeLa (cervical carcinoma) | 15.2 | Cancer cell line |
| HEK293 (embryonic kidney) | 8.7 | Common lab line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.214G>A (p.Gly72Ser) | Missense | <0.01% | Unknown functional impact |
| c.389C>T (p.Pro130Leu) | Missense | <0.01% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression in tumors suggests potential gain-of-function role in cancer.
Dominant Negative (DN)
Not documented.
View complete mutation data：
Gene Ontology (GO)
| • actin binding (GO:0003779) | • structural constituent of cytoskeleton (GO:0005200) |
| • microtubule (GO:0005874) | • microtubule-based process (GO:0007017) |
| • cell projection organization (GO:0030030) |
Pathways
• Microtubule dynamics (Reactome: R-HSA-983231)
• Stathmin family pathway (KEGG: hsa04540)
Protein Summary
The STMN3 protein (UniProt Q9NZ72) is a 179-amino-acid stathmin family member that binds tubulin heterodimers, reducing microtubule polymerization. It is predominantly expressed in neurons and plays a role in axonal growth, synaptic vesicle trafficking, and cell migration. Post-translational modifications, including phosphorylation, regulate its activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STMN3 Knockout HEK293 Cell Line | EDJ-KQ10838 | Human | 50861 | Details Get a Quote |
| STMN3 Knockout A-549 Cell Line | EDJ-KQ38492 | Human | 50861 | Details Get a Quote |
| STMN3 Knockout HCT 116 Cell Line | EDJ-KQ38493 | Human | 50861 | Details Get a Quote |
| STMN3 Knockout HeLa Cell Line | EDJ-KQ38494 | Human | 50861 | Details Get a Quote |
