STK33: Serine/Threonine Kinase 33
A kinase with emerging roles in cancer and cellular signaling
Gene Information Card
| Symbol | STK33 |
|---|---|
| Full Name | Serine/Threonine Kinase 33 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 65975 ncbi.nlm.nih.gov/gene/65975 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | Q9BVT8 |
| OMIM ID | 607670 |
| HGNC ID | 14568 |
| Aliases | SgK493, MGC131930 |
Description
STK33 (serine/threonine kinase 33) is a protein-coding gene located on chromosome 11p15.4. It encodes a member of the calcium/calmodulin-dependent kinase family. STK33 is involved in cellular signaling, particularly in the regulation of cell survival and proliferation. Its expression is elevated in certain cancers, and it has been studied as a potential therapeutic target, especially in acute myeloid leukemia and lung cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute Myeloid Leukemia | STK33 overexpression promotes cell survival via phosphorylation of downstream targets; inhibition reduces viability | PMID: 22323542 |
| Non-Small Cell Lung Cancer | STK33 knockdown reduces tumor growth in KRAS-dependent cell lines | PMID: 21909107 |
| Colorectal Cancer | STK33 upregulation associated with poor prognosis; promotes proliferation via AKT/mTOR pathway | PMID: 31092905 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Bone Marrow | 8.7 | Low |
| Lung | 6.2 | Low |
| Colon | 5.1 | Low |
| Brain | 2.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Embryonic kidney; high expression |
| A549 | 9.8 | Lung adenocarcinoma; moderate |
| HCT116 | 7.4 | Colorectal carcinoma; moderate |
| K562 | 6.1 | Chronic myeloid leukemia; low |
| MCF7 | 3.5 | Breast cancer; low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1042C>T (p.Arg348Trp) | Missense | <0.01% | Unknown functional impact; reported in COSMIC |
| c.1283G>A (p.Arg428Gln) | Missense | <0.01% | Reported in COSMIC; no known disease association |
| c.1546_1547insA (p.Thr516Asnfs*2) | Frameshift | <0.01% | Predicted loss-of-function; rare |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr516Asnfs*2) are predicted to cause loss of kinase activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in curated databases.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004672 (GO:0004672) | • GO:0005524 (GO:0005524) |
| • GO:0006468 (GO:0006468) | • GO:0016301 (GO:0016301) |
| • GO:0016310 (GO:0016310) | • GO:0046777 (GO:0046777) |
Pathways
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• MAPK signaling pathway (KEGG: hsa04010)
• Kinase signaling in cancer (Reactome: R-HSA-5663202)
Protein Summary
STK33 is a 488-amino acid serine/threonine kinase with a catalytic domain typical of the CAMK family. It localizes to the cytoplasm and nucleus. The protein phosphorylates substrates involved in cell cycle progression and apoptosis. STK33 has been implicated in the survival of KRAS-dependent cancer cells, though its exact physiological substrates remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK33 Knockout HEK293 Cell Line | EDJ-KQ12075 | Human | 65975 | Details Get a Quote |
| STK33 Knockout HeLa Cell Line | EDJ-KQ39475 | Human | 65975 | Details Get a Quote |
| STK33 Knockout A-549 Cell Line | EDJ-KQ40730 | Human | 65975 | Details Get a Quote |
| STK33 Knockout HCT 116 Cell Line | EDJ-KQ40731 | Human | 65975 | Details Get a Quote |
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