STK32C
Serine/Threonine Kinase 32C
Gene Information Card
| Symbol | STK32C |
|---|---|
| Full Name | Serine/Threonine Kinase 32C |
| Gene Type | Protein coding |
| Chromosomal Location | 10q26.13 |
| NCBI Gene ID | 282974 ncbi.nlm.nih.gov/gene/282974 |
| Ensembl ID | ENSG00000165752 |
| UniProt ID | Q86UX6 |
| OMIM ID | 608728 |
| HGNC ID | 20235 |
| Aliases | YANK3, SgK396 |
Description
STK32C (serine/threonine kinase 32C) is a protein-coding gene that encodes a member of the serine/threonine protein kinase family. The encoded protein is also known as YANK3 (Yet Another Novel Kinase 3) and SgK396. It is involved in intracellular signaling pathways, likely regulating cell proliferation and differentiation. The gene is located on chromosome 10q26.13 and is expressed in various tissues, with notable levels in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No direct evidence from ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 7.8 | Medium |
| Testis | 6.5 | Medium |
| Thyroid | 4.2 | Low |
| Lung | 3.1 | Low |
| Heart | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 5.0 | Moderate expression |
| K562 | 3.2 | Low expression |
| HeLa | 2.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function variants in ClinVar or COSMIC.
Gain of Function (GOF)
No documented gain-of-function variants.
Dominant Negative (DN)
No documented dominant-negative variants.
View complete mutation data：
Gene Ontology (GO)
| • Protein serine/threonine kinase activity | • ATP binding |
| • Intracellular signal transduction | • Protein phosphorylation |
Pathways
• No specific pathway annotations in Reactome or KEGG
Protein Summary
The STK32C protein (UniProt Q86UX6) is a serine/threonine kinase of 396 amino acids. It contains a catalytic kinase domain and is predicted to phosphorylate protein substrates, modulating cellular signaling. Its precise biological roles remain under investigation, but it is thought to contribute to neuronal and reproductive tissue function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK32C Knockout HEK293 Cell Line | EDJ-KQ15542 | Human | 282974 | Details Get a Quote |
| STK32C Knockout A-549 Cell Line | EDJ-KQ46386 | Human | 282974 | Details Get a Quote |
| STK32C Knockout HCT 116 Cell Line | EDJ-KQ46387 | Human | 282974 | Details Get a Quote |
| STK32C Knockout HeLa Cell Line | EDJ-KQ46388 | Human | 282974 | Details Get a Quote |
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