STK32B: Serine/Threonine Kinase 32B
A member of the CAMK family with roles in cell signaling and potential links to cancer and neurological disorders.
Gene Information Card
| Symbol | STK32B |
|---|---|
| Full Name | Serine/Threonine Kinase 32B |
| Gene Type | Protein coding |
| Chromosomal Location | 4p16.2 |
| NCBI Gene ID | 55351 ncbi.nlm.nih.gov/gene/55351 |
| Ensembl ID | ENSG00000138668 |
| UniProt ID | Q9NY57 |
| OMIM ID | 609367 |
| HGNC ID | 11405 |
| Aliases | YANK2, STK32B1, STK32B2 |
Description
STK32B (serine/threonine kinase 32B) encodes a member of the calcium/calmodulin-dependent protein kinase (CAMK) family. The protein, also known as YANK2, is involved in intracellular signaling cascades, particularly those regulating cell cycle and cytoskeletal dynamics. Alternative splicing generates multiple transcript variants. STK32B has been implicated in cancer progression and neurological conditions, though its precise physiological roles remain under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression and copy number gain; potential oncogenic role via kinase signaling | COSMIC; PMID: 25691885 |
| Lung adenocarcinoma | Somatic mutations (e.g., missense) observed; possible driver alteration | COSMIC; PMID: 22980975 |
| Schizophrenia | GWAS association; variant rs13107325 in linkage disequilibrium | ClinVar; PMID: 25056061 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Low |
| Heart | 6.1 | Low |
| Lung | 4.7 | Low |
| Breast | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 5.8 | Moderate expression |
| A549 (lung cancer) | 4.1 | Low expression |
| HEK293 (embryonic kidney) | 3.5 | Low expression |
| SH-SY5Y (neuroblastoma) | 7.2 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.Glu182Lys | Missense | <0.1% | Unknown; predicted possibly damaging |
| p.Arg207Trp | Missense | <0.1% | Unknown; predicted benign |
| p.Thr442Met | Missense | <0.1% | Unknown; predicted possibly damaging |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function variants reported; overexpression in some cancers suggests potential oncogenic role.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • ATP binding |
| • intracellular signal transduction | • protein phosphorylation |
| • cytosol |
Pathways
• MAPK signaling pathway (KEGG hsa04010)
• Calcium signaling pathway (KEGG hsa04020)
Protein Summary
STK32B (YANK2) is a 548-amino acid serine/threonine kinase with a catalytic domain typical of CAMK family members. It localizes to the cytosol and is involved in phosphorylation of downstream targets. Structural studies indicate a conserved kinase fold with regulatory regions. The protein is expressed in brain and testis, with lower levels in other tissues. Its kinase activity is thought to be regulated by calcium/calmodulin binding, though direct evidence is limited.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK32B Knockout HEK293 Cell Line | EDJ-KQ15541 | Human | 55351 | Details Get a Quote |
| STK32B Knockout A-549 Cell Line | EDJ-KQ46384 | Human | 55351 | Details Get a Quote |
| STK32B Knockout HeLa Cell Line | EDJ-KQ46385 | Human | 55351 | Details Get a Quote |
| STK32B Knockout HCT 116 Cell Line | EDJ-KQ73525 | Human | 55351 | Details Get a Quote |
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