STK32A
Serine/Threonine Kinase 32A
Gene Information Card
| Symbol | STK32A |
|---|---|
| Full Name | Serine/Threonine Kinase 32A |
| Gene Type | Protein coding |
| Chromosomal Location | 5q32 |
| NCBI Gene ID | 202374 ncbi.nlm.nih.gov/gene/202374 |
| Ensembl ID | ENSG00000169302 |
| UniProt ID | Q8WY21 |
| OMIM ID | 609370 |
| HGNC ID | 28397 |
| Aliases | YANK1, STK32 |
Description
STK32A (serine/threonine kinase 32A) is a protein-coding gene that belongs to the serine/threonine protein kinase family. It encodes a kinase that phosphorylates serine and threonine residues on target proteins, playing a role in cellular signaling pathways. The gene is located on chromosome 5q32 and is also known as YANK1 (Yet Another Novel Kinase 1).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered kinase activity may promote oncogenic signaling | COSMIC database reports somatic mutations in multiple cancer types |
| No specific Mendelian disease association | Not established | OMIM does not list a disease phenotype |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Heart | 6.1 | Low |
| Liver | 1.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.0 | Moderate expression |
| HeLa | 9.5 | Low expression |
| K562 | 3.2 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.R391H | Missense | <0.1% in COSMIC | Unknown functional effect |
| p.G210V | Missense | <0.1% in COSMIC | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant negative effects.
View complete mutation data：
Gene Ontology (GO)
| • Protein serine/threonine kinase activity | • ATP binding |
| • Protein phosphorylation | • Intracellular signal transduction |
Pathways
• No specific curated pathways in Reactome or KEGG for STK32A
Protein Summary
STK32A encodes a 454-amino acid protein with a serine/threonine kinase domain. It is predicted to localize to the cytoplasm and nucleus. The protein is involved in phosphorylation-dependent signaling, though specific substrates and biological functions remain largely uncharacterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK32A Knockout HEK293 Cell Line | EDJ-KQ5195 | Human | 202374 | Details Get a Quote |
| STK32A Knockout A-549 Cell Line | EDJ-KQ28191 | Human | 202374 | Details Get a Quote |
| STK32A Knockout HeLa Cell Line | EDJ-KQ59033 | Human | 202374 | Details Get a Quote |
| STK32A Knockout HCT 116 Cell Line | EDJ-KQ75910 | Human | 202374 | Details Get a Quote |
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