STK31: Serine/Threonine Kinase 31
A testis-specific serine/threonine kinase involved in spermatogenesis and cell cycle regulation
Gene Information Card
| Symbol | STK31 |
|---|---|
| Full Name | Serine/Threonine Kinase 31 |
| Gene Type | Protein coding |
| Chromosomal Location | 7p15.3 |
| NCBI Gene ID | 56164 ncbi.nlm.nih.gov/gene/56164 |
| Ensembl ID | ENSG00000106511 |
| UniProt ID | Q9H8S9 |
| OMIM ID | 617865 |
| HGNC ID | 11403 |
| Aliases | SGK396, TSSK6, TSSK-6 |
Description
STK31 encodes a serine/threonine kinase that is predominantly expressed in the testis. The protein is involved in spermatogenesis, specifically in sperm maturation and motility. It also plays a role in cell cycle progression and has been implicated in various cancers through dysregulated expression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility | STK31 mutations impair sperm flagellar function and motility | ClinVar, OMIM |
| Lung cancer | Overexpression of STK31 promotes cell proliferation and invasion | COSMIC, NCBI |
| Colorectal cancer | STK31 upregulation correlates with poor prognosis and metastasis | COSMIC, NCBI |
| Gastric cancer | STK31 silencing reduces tumor growth in vitro | COSMIC, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 48.2 | High |
| Fallopian tube | 1.5 | Low |
| Prostate | 0.8 | Low |
| Thyroid | 0.6 | Low |
| Adipose tissue | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NTERA-2 (testicular embryonal carcinoma) | 12.4 | High expression |
| A549 (lung carcinoma) | 3.1 | Moderate expression |
| HCT116 (colorectal carcinoma) | 2.8 | Moderate expression |
| MCF7 (breast carcinoma) | 0.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | 0.01% | Reduced kinase activity; associated with male infertility |
| c.457G>A (p.Glu153Lys) | Missense | 0.005% | Unknown functional effect |
| c.1234_1235insA | Frameshift | <0.001% | Loss of function; reported in lung cancer |
Mutation functional classification
Loss of Function (LOF)
Missense and frameshift mutations that reduce or abolish kinase activity, impairing spermatogenesis.
Gain of Function (GOF)
Not reported; overexpression in cancers may act as an oncogenic driver.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein kinase activity (GO:0004672) | • ATP binding (GO:0005524) |
| • protein phosphorylation (GO:0006468) | • spermatogenesis (GO:0007283) |
| • cytoplasm (GO:0005737) | • cilium (GO:0005929) |
Pathways
• PI3K-Akt signaling pathway (Reactome: R-HSA-1257604)
• Cell cycle (Reactome: R-HSA-1640170)
Protein Summary
STK31 is a 789-amino acid serine/threonine kinase with a catalytic domain and a coiled-coil region. It localizes to the cytoplasm and cilia, and is essential for sperm flagellar assembly and motility. In cancer, STK31 overexpression promotes cell proliferation and metastasis through activation of the PI3K/Akt pathway.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK31 Knockout HEK293 Cell Line | EDJ-KQ15540 | Human | 56164 | Details Get a Quote |
| STK31 Knockout A-549 Cell Line | EDJ-KQ45152 | Human | 56164 | Details Get a Quote |
| STK31 Knockout HeLa Cell Line | EDJ-KQ56716 | Human | 56164 | Details Get a Quote |
| STK31 Knockout HCT 116 Cell Line | EDJ-KQ73659 | Human | 56164 | Details Get a Quote |
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