STK17A
Serine/Threonine Kinase 17A (DAP Kinase-Related Apoptosis-Inducing Protein Kinase 1)
Gene Information Card
| Symbol | STK17A |
|---|---|
| Full Name | Serine/Threonine Kinase 17A |
| Gene Type | Protein coding |
| Chromosomal Location | 7p12.3 |
| NCBI Gene ID | 9263 ncbi.nlm.nih.gov/gene/9263 |
| Ensembl ID | ENSG00000164543 |
| UniProt ID | Q9UEE5 |
| OMIM ID | 604726 |
| HGNC ID | 11396 |
| Aliases | DRAK1, DAP kinase-related apoptosis-inducing protein kinase 1 |
Description
STK17A (serine/threonine kinase 17a) encodes a member of the death-associated protein (DAP) kinase family. The protein, also known as DRAK1, is a nuclear serine/threonine kinase that positively regulates apoptosis. It is involved in the phosphorylation of myosin light chain and plays a role in cell death signaling, particularly in response to DNA damage. STK17A is expressed in various tissues and has been implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Dysregulation of apoptosis; altered STK17A expression may promote tumorigenesis | NCBI Gene, COSMIC |
| Breast cancer | Reduced expression associated with poor prognosis | ClinVar, COSMIC |
| Colorectal cancer | Mutations and altered expression observed | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 8.2 | Medium |
| Lung | 6.1 | Low |
| Brain | 4.3 | Low |
| Liver | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 10.5 | Cervical cancer cell line |
| A549 | 7.8 | Lung cancer cell line |
| MCF7 | 5.2 | Breast cancer cell line |
| HEK293 | 4.0 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.1% | Unknown functional effect |
| c.1246G>A (p.Gly416Arg) | Missense | <0.1% | Unknown functional effect |
| c.1453_1454del (p.Leu485fs) | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Leu485fs) are predicted to cause loss of kinase activity and impaired apoptosis.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein serine/threonine kinase activity | • ATP binding |
| • apoptotic process | • protein phosphorylation |
| • nucleus | • cytoplasm |
Pathways
• Apoptosis
• p53 signaling pathway
• DAP kinase signaling
Protein Summary
STK17A (DRAK1) is a 448-amino acid serine/threonine kinase with a catalytic domain and a nuclear localization signal. It phosphorylates myosin light chain and other substrates to promote apoptosis. The protein is predominantly nuclear and is activated by DNA damage. Its expression is regulated in a tissue-specific manner, and alterations are linked to cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK17A Knockout HEK293 Cell Line | EDJ-KQ2763 | Human | 9263 | Details Get a Quote |
| STK17A Knockout A-549 Cell Line | EDJ-KQ23669 | Human | 9263 | Details Get a Quote |
| STK17A Knockout HCT 116 Cell Line | EDJ-KQ23670 | Human | 9263 | Details Get a Quote |
| STK17A Knockout HeLa Cell Line | EDJ-KQ23671 | Human | 9263 | Details Get a Quote |
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