STK16: Serine/Threonine Kinase 16
A pseudokinase involved in Golgi dynamics and cellular signaling
Gene Information Card
| Symbol | STK16 |
|---|---|
| Full Name | Serine/Threonine Kinase 16 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q35 |
| NCBI Gene ID | 8576 ncbi.nlm.nih.gov/gene/8576 |
| Ensembl ID | ENSG00000115657 |
| UniProt ID | O75716 |
| OMIM ID | 606200 |
| HGNC ID | 11401 |
| Aliases | MST-16, KRICT, PKL12, TSF-1 |
Description
STK16 (serine/threonine kinase 16) encodes a member of the NAK (Numb-associated kinase) family of serine/threonine kinases. Although it possesses a kinase domain, it is considered a pseudokinase due to lack of critical catalytic residues. STK16 localizes to the Golgi apparatus and is involved in Golgi dynamics, vesicle trafficking, and cell cycle regulation. It interacts with Numb and may play a role in asymmetric cell division and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | STK16 overexpression correlates with poor prognosis; may promote proliferation via Golgi signaling | COSMIC, literature |
| Colorectal cancer | Mutations and altered expression observed; potential role in tumor progression | COSMIC, literature |
| Lung cancer | Somatic mutations reported; functional impact under investigation | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 15.2 | Medium |
| Kidney | 10.1 | Medium |
| Testis | 22.4 | High |
| Lung | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.5 | Cervical cancer cell line |
| HEK293 | 11.2 | Embryonic kidney cell line |
| MCF7 | 18.3 | Breast cancer cell line |
| A549 | 9.7 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497G>A (p.Arg166Gln) | Missense | <0.1% | Unknown; predicted benign |
| c.1012C>T (p.Arg338Trp) | Missense | <0.1% | Unknown; predicted damaging |
| c.1345_1346insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.1345_1346insA) likely cause loss of function due to truncated protein.
Gain of Function (GOF)
No clear gain-of-function mutations reported.
Dominant Negative (DN)
Not established.
View complete mutation data：
Gene Ontology (GO)
| • Golgi apparatus | • protein serine/threonine kinase activity |
| • ATP binding | • vesicle-mediated transport |
| • cell cycle | • protein phosphorylation |
Pathways
• Numb-mediated signaling
• Golgi vesicle transport
Protein Summary
STK16 is a 305-amino acid pseudokinase that localizes to the Golgi apparatus. It contains a kinase-like domain but lacks catalytic activity due to substitutions in the ATP-binding and catalytic loops. STK16 interacts with Numb and regulates Golgi morphology and vesicle trafficking. It is widely expressed, with highest levels in testis and certain cancer cell lines. Mutations are rare but may contribute to cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK16 Knockout HEK293 Cell Line | EDJ-KQ50799 | Human | 8576 | Details Get a Quote |
| STK16 Knockout HeLa Cell Line | EDJ-KQ54945 | Human | 8576 | Details Get a Quote |
| STK16 Knockout A-549 Cell Line | EDJ-KQ63430 | Human | 8576 | Details Get a Quote |
| STK16 Knockout HCT 116 Cell Line | EDJ-KQ71896 | Human | 8576 | Details Get a Quote |
