STEAP3: Six-Transmembrane Epithelial Antigen of the Prostate 3
A key regulator of iron homeostasis and erythroid development, implicated in anemia and cancer.
Gene Information Card
| Symbol | STEAP3 |
|---|---|
| Full Name | STEAP3 metalloreductase |
| Gene Type | Protein coding |
| Chromosomal Location | 2q14.2 |
| NCBI Gene ID | 55240 ncbi.nlm.nih.gov/gene/55240 |
| Ensembl ID | ENSG00000115107 |
| UniProt ID | Q8TAX7 |
| OMIM ID | 609671 |
| HGNC ID | 24587 |
| Aliases | TSAP6, dudulin-2, pHyde |
Description
STEAP3 (Six-Transmembrane Epithelial Antigen of the Prostate 3) encodes a transmembrane protein that functions as a ferrireductase, reducing Fe3+ to Fe2+ for cellular iron uptake. It is essential for erythroid maturation and iron homeostasis. The gene is also implicated in apoptosis regulation and tumor suppression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Anemia, hypochromic microcytic, with iron overload | Loss-of-function mutations impair ferrireductase activity, reducing iron availability for erythropoiesis | OMIM #609671, ClinVar |
| Prostate cancer | Downregulation or loss of STEAP3 may contribute to tumor progression; proposed tumor suppressor role | COSMIC, NCBI Gene |
| Breast cancer | Altered expression linked to poor prognosis; potential role in iron-dependent proliferation | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 28.5 | Medium |
| Liver | 15.2 | Medium |
| Spleen | 12.8 | Medium |
| Prostate | 8.1 | Low |
| Testis | 6.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 35.0 | High expression; erythroid lineage |
| HepG2 (liver) | 20.1 | Moderate expression |
| MCF7 (breast) | 5.2 | Low expression |
| PC-3 (prostate) | 3.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.304C>T (p.Arg102Trp) | Missense | Rare | Loss of ferrireductase activity; associated with anemia |
| c.577G>A (p.Gly193Arg) | Missense | Rare | Impaired protein function; reported in iron deficiency |
| c.1A>G (p.Met1Val) | Start loss | Very rare | Complete loss of protein; severe anemia |
Mutation functional classification
Loss of Function (LOF)
Missense and start-loss mutations reduce or abolish ferrireductase activity, leading to iron deficiency anemia.
Gain of Function (GOF)
Not reported in literature or curated databases.
Dominant Negative (DN)
Not reported; recessive inheritance pattern observed.
View complete mutation data：
Gene Ontology (GO)
| • cytoplasm (GO:0005737) | • integral component of membrane (GO:0016021) |
| • ferrous iron binding (GO:0008198) | • ferric iron binding (GO:0008199) |
| • ferric-chelate reductase activity (GO:0000293) | • cellular iron ion homeostasis (GO:0006879) |
| • iron ion transport (GO:0033572) | • erythrocyte maturation (GO:0048821) |
Pathways
• Iron uptake and transport (Reactome: R-HSA-917937)
• Erythropoietin signaling (Reactome: R-HSA-9006335)
Protein Summary
STEAP3 is a 488-amino acid transmembrane protein with six membrane-spanning domains. It localizes to the plasma membrane and endosomes, where it reduces extracellular or endosomal Fe3+ to Fe2+ for transport via DMT1. The protein also exhibits NADPH oxidase activity and is involved in p53-dependent apoptosis. Its expression is highest in erythroid tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STEAP3 Knockout HEK293 Cell Line | EDJ-KQ15537 | Human | 55240 | Details Get a Quote |
| STEAP3 Knockout A-549 Cell Line | EDJ-KQ46377 | Human | 55240 | Details Get a Quote |
| STEAP3 Knockout HCT 116 Cell Line | EDJ-KQ46378 | Human | 55240 | Details Get a Quote |
| STEAP3 Knockout HeLa Cell Line | EDJ-KQ46379 | Human | 55240 | Details Get a Quote |
