STEAP2: A Metalloreductase in Prostate Cancer and Iron Homeostasis
Explore STEAP2 gene function, expression, mutations, and disease associations with curated data from NCBI, Ensembl, UniProt, OMIM, HGNC, COSMIC, and ClinVar.
Gene Information Card
| Symbol | STEAP2 |
|---|---|
| Full Name | STEAP family member 2 |
| Gene Type | protein coding |
| Chromosomal Location | 7q21.13 |
| NCBI Gene ID | 261729 ncbi.nlm.nih.gov/gene/261729 |
| Ensembl ID | ENSG00000157214 |
| UniProt ID | Q8NFT2 |
| OMIM ID | 605091 |
| HGNC ID | 16910 |
| Aliases | STAMP1, TIARP, STEAP2A, STEAP2B |
Description
STEAP2 (STEAP family member 2) encodes a six-transmembrane protein that functions as a metalloreductase, reducing Fe3+ to Fe2+ and Cu2+ to Cu1+, thereby facilitating metal ion uptake. It is highly expressed in prostate tissue and is implicated in prostate cancer progression, iron homeostasis, and oxidative stress response. STEAP2 is also involved in cell proliferation and may play a role in tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | Overexpression of STEAP2 promotes cell proliferation and invasion; may regulate androgen receptor signaling. | COSMIC: increased expression in prostate tumors; PMID: 14559847 |
| Colorectal Cancer | Upregulation of STEAP2 correlates with poor prognosis; may enhance iron uptake to support tumor growth. | COSMIC: somatic mutations; PMID: 25689618 |
| Iron Metabolism Disorders | Altered STEAP2 expression affects iron homeostasis, potentially contributing to anemia or iron overload. | UniProt: function in iron reduction; PMID: 16959783 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 31.2 | High |
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Brain | 4.1 | Low |
| Lung | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 45.6 | High expression |
| LNCaP (prostate cancer) | 38.9 | High expression |
| HepG2 (liver cancer) | 15.2 | Moderate |
| A549 (lung cancer) | 3.4 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Asp38Asn) | Missense | 0.01% (gnomAD) | Unknown; predicted benign |
| c.454C>T (p.Arg152Trp) | Missense | 0.02% (gnomAD) | May affect protein stability |
| c.789_790del (p.Glu264fs) | Frameshift | Rare | Loss of function; associated with reduced metalloreductase activity |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein lead to loss of metalloreductase activity, impairing iron and copper uptake.
Gain of Function (GOF)
Missense mutations that increase enzyme activity or protein stability could enhance metal uptake and promote tumor growth, though not well-documented.
Dominant Negative (DN)
No evidence for dominant-negative effects; STEAP2 likely functions as a homodimer, but mutations that disrupt dimerization could exert dominant-negative effects, yet not reported.
View complete mutation data：
Gene Ontology (GO)
| • oxidoreductase activity | • ferric-chelate reductase activity |
| • cupric reductase activity | • metal ion binding |
| • plasma membrane | • integral component of membrane |
| • cell proliferation | • iron ion homeostasis |
Pathways
• Iron uptake and metabolism
• Copper homeostasis
• Reactive oxygen species (ROS) response
Protein Summary
STEAP2 is a 490-amino acid transmembrane protein with six membrane-spanning domains. It localizes to the plasma membrane and endosomes, where it reduces Fe3+ and Cu2+ using NADPH as an electron donor. The protein forms homodimers and may interact with other STEAP family members. STEAP2 is highly expressed in the prostate and is upregulated in prostate cancer, where it promotes cell growth and survival. It also plays a role in iron homeostasis in various tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STEAP2 Knockout HEK293 Cell Line | EDJ-KQ15536 | Human | 261729 | Details Get a Quote |
| STEAP2 Knockout HCT 116 Cell Line | EDJ-KQ45144 | Human | 261729 | Details Get a Quote |
| STEAP2 Knockout A-549 Cell Line | EDJ-KQ46375 | Human | 261729 | Details Get a Quote |
| STEAP2 Knockout HeLa Cell Line | EDJ-KQ59351 | Human | 261729 | Details Get a Quote |
