STARD7
StAR Related Lipid Transfer Domain Containing 7
Gene Information Card
| Symbol | STARD7 |
|---|---|
| Full Name | StAR Related Lipid Transfer Domain Containing 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 56910 ncbi.nlm.nih.gov/gene/56910 |
| Ensembl ID | ENSG00000115966 |
| UniProt ID | Q9NQZ5 |
| OMIM ID | 616688 |
| HGNC ID | 25477 |
| Aliases | GTT1, MGC138499, MGC138500 |
Description
STARD7 (StAR Related Lipid Transfer Domain Containing 7) encodes a protein belonging to the StarD family of lipid transfer proteins. The protein contains a StAR-related lipid transfer (START) domain and is involved in intracellular lipid transport, particularly of cholesterol and phospholipids. It is localized to the cytoplasm and mitochondria and plays a role in mitochondrial lipid homeostasis and cell proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered STARD7 expression may affect lipid metabolism and cell growth, contributing to tumorigenesis. | COSMIC; literature |
| Mitochondrial disorders | Defective lipid transfer to mitochondria may impair mitochondrial function. | UniProt; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Heart | 6.1 | Low |
| Brain | 4.2 | Low |
| Lung | 9.7 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | High expression |
| HEK293 | 11.8 | Medium expression |
| HepG2 | 13.5 | High expression |
| A549 | 10.1 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437C>T (p.Pro146Leu) | Missense | <0.01% | Unknown functional impact |
| c.784G>A (p.Gly262Arg) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant negative effects.
View complete mutation data：
Gene Ontology (GO)
| • lipid transport | • cholesterol transport |
| • phospholipid transport | • mitochondrion |
| • cytoplasm | • START domain |
Pathways
• Lipid transport
• Mitochondrial lipid metabolism
Protein Summary
STARD7 is a 30 kDa protein containing a START domain that binds and transports lipids. It is primarily cytoplasmic but can associate with mitochondria, where it facilitates the transfer of phospholipids and cholesterol. The protein is expressed in multiple tissues and is implicated in cellular lipid homeostasis and cancer biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STARD7 Knockout HEK293 Cell Line | EDJ-KQ15533 | Human | 56910 | Details Get a Quote |
| STARD7 Knockout A-549 Cell Line | EDJ-KQ46366 | Human | 56910 | Details Get a Quote |
| STARD7 Knockout HCT 116 Cell Line | EDJ-KQ46367 | Human | 56910 | Details Get a Quote |
| STARD7 Knockout HeLa Cell Line | EDJ-KQ46368 | Human | 56910 | Details Get a Quote |
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