STARD13
StAR-related lipid transfer domain containing 13
Gene Information Card
| Symbol | STARD13 |
|---|---|
| Full Name | StAR-related lipid transfer domain containing 13 |
| Gene Type | protein-coding |
| Chromosomal Location | 13q13.1 |
| NCBI Gene ID | 90627 ncbi.nlm.nih.gov/gene/90627 |
| Ensembl ID | ENSG00000133121 |
| UniProt ID | Q9Y3M8 |
| OMIM ID | 608866 |
| HGNC ID | 19107 |
| Aliases | DLC2, KIAA1089, STARD13-AS1 |
Description
STARD13 encodes a protein containing a StAR-related lipid transfer (START) domain and a RhoGAP domain. It functions as a GTPase-activating protein for RhoA and Cdc42, regulating cell migration, proliferation, and cytoskeletal dynamics. The gene is frequently deleted or downregulated in various cancers, acting as a tumor suppressor.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Loss of STARD13 expression leads to increased RhoA activity and enhanced cell migration/invasion | PMID: 15696293 |
| Breast cancer | Reduced STARD13 expression correlates with poor prognosis and metastasis | PMID: 17938248 |
| Colorectal cancer | Promoter hypermethylation silences STARD13, promoting tumor growth | PMID: 19137073 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 5.2 | Low |
| Breast | 3.8 | Low |
| Colon | 4.1 | Low |
| Lung | 6.0 | Medium |
| Brain | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 4.5 | Hepatocellular carcinoma cell line |
| MCF7 | 3.2 | Breast cancer cell line |
| HeLa | 5.8 | Cervical cancer cell line |
| A549 | 6.1 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1129C>T (p.Arg377*) | Nonsense | <1% | Loss of function |
| c.1456G>A (p.Glu486Lys) | Missense | <1% | Unknown |
| c.1687_1688del (p.Leu563fs) | Frameshift | <1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations truncate the protein, abolishing RhoGAP activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Rho GTPase cycle (Reactome: R-HSA-194840)
• Signaling by Rho GTPases (Reactome: R-HSA-194315)
Protein Summary
STARD13 is a 1113-amino acid protein with an N-terminal SAM domain, a central RhoGAP domain, and a C-terminal START domain. The RhoGAP domain inactivates RhoA and Cdc42 by stimulating GTP hydrolysis, thereby inhibiting actin cytoskeleton reorganization and cell motility. The START domain may mediate lipid binding or transfer. The protein localizes to the cytoplasm and is involved in tumor suppression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STARD13 Knockout HEK293 Cell Line | EDJ-KQ3917 | Human | 90627 | Details Get a Quote |
| STARD13 Knockout A-549 Cell Line | EDJ-KQ26141 | Human | 90627 | Details Get a Quote |
| STARD13 Knockout HCT 116 Cell Line | EDJ-KQ26142 | Human | 90627 | Details Get a Quote |
| STARD13 Knockout HeLa Cell Line | EDJ-KQ26143 | Human | 90627 | Details Get a Quote |
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