STARD10: A Key Regulator of Phospholipid Metabolism and Signaling
Comprehensive genomic and proteomic analysis of STARD10, a steroidogenic acute regulatory protein-related lipid transfer domain-containing protein involved in cellular lipid homeostasis and cancer.
Gene Information Card
| Symbol | STARD10 |
|---|---|
| Full Name | StAR-related lipid transfer domain containing 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 10809 ncbi.nlm.nih.gov/gene/10809 |
| Ensembl ID | ENSG00000148848 |
| UniProt ID | Q9Y365 |
| OMIM ID | 606091 |
| HGNC ID | 11373 |
| Aliases | CGI-52, NY-CO-28, SDCCAG28, START domain containing 10 |
Description
STARD10 encodes a member of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family. The protein is involved in intracellular lipid transport, specifically phosphatidylcholine and phosphatidylethanolamine, and plays a role in phospholipid metabolism, cell signaling, and potentially in cancer progression. It is localized to the cytoplasm and endoplasmic reticulum.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Overexpression of STARD10 is associated with poor prognosis; may promote cell proliferation and migration via altered phospholipid signaling. | PMID: 23454728; COSMIC |
| Colorectal Cancer | STARD10 expression is upregulated in tumor tissues; linked to lipid metabolism reprogramming. | PMID: 25670082; COSMIC |
| Hepatocellular Carcinoma | STARD10 knockdown reduces cell growth and induces apoptosis; potential therapeutic target. | PMID: 28708999 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Breast | 6.1 | Low |
| Colon | 5.4 | Low |
| Lung | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Hepatocellular carcinoma cell line |
| MCF7 | 7.8 | Breast cancer cell line |
| HT-29 | 6.5 | Colorectal adenocarcinoma cell line |
| A549 | 5.1 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | 0.02% (gnomAD) | Unknown; predicted benign by SIFT |
| c.487G>A (p.Gly163Ser) | Missense | 0.01% (gnomAD) | Unknown; predicted possibly damaging by PolyPhen |
| c.601C>T (p.Arg201Trp) | Missense | <0.01% (COSMIC) | Reported in colorectal cancer; functional impact unclear |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in literature or databases.
Gain of Function (GOF)
Overexpression in cancer suggests potential gain-of-function role in tumorigenesis.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • lipid binding (GO:0008289) | • lipid transport (GO:0006869) |
| • phospholipid transporter activity (GO:0005548) | • cholesterol transporter activity (GO:0017127) |
| • endoplasmic reticulum (GO:0005783) | • cytoplasm (GO:0005737) |
Pathways
• Phospholipid metabolism
• Lipid transport
• Sphingolipid signaling pathway (Reactome: R-HSA-428157)
Protein Summary
STARD10 is a 290-amino acid protein containing a single START domain that binds and transfers phospholipids, particularly phosphatidylcholine and phosphatidylethanolamine. It is involved in lipid homeostasis at the endoplasmic reticulum and may influence cell signaling, proliferation, and survival. Overexpression in several cancers suggests a role in tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STARD10 Knockout HEK293 Cell Line | EDJ-KQ7184 | Human | 10809 | Details Get a Quote |
| STARD10 Knockout A-549 Cell Line | EDJ-KQ32121 | Human | 10809 | Details Get a Quote |
| STARD10 Knockout HCT 116 Cell Line | EDJ-KQ32122 | Human | 10809 | Details Get a Quote |
| STARD10 Knockout HeLa Cell Line | EDJ-KQ32123 | Human | 10809 | Details Get a Quote |
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