STAM2: Signal Transducing Adaptor Molecule 2
A key adaptor protein in endosomal sorting and receptor signaling
Gene Information Card
| Symbol | STAM2 |
|---|---|
| Full Name | Signal transducing adaptor molecule 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q23.3 |
| NCBI Gene ID | 10254 ncbi.nlm.nih.gov/gene/10254 |
| Ensembl ID | ENSG00000115145 |
| UniProt ID | O75886 |
| OMIM ID | 606464 |
| HGNC ID | 11358 |
| Aliases | Hbp, STAM2A, STAM2B |
Description
STAM2 (Signal Transducing Adaptor Molecule 2) encodes a member of the STAM family of adaptor proteins. It is a component of the ESCRT-0 complex involved in endosomal sorting of ubiquitinated cargo, including activated receptor tyrosine kinases. STAM2 also participates in cytokine and growth factor signaling pathways, regulating receptor downregulation and intracellular trafficking.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of endosomal sorting and receptor signaling; STAM2 overexpression or mutation may alter growth factor receptor turnover | COSMIC; literature (e.g., PMID: 12477932) |
| Hepatocellular carcinoma | STAM2 upregulation associated with poor prognosis; potential role in EGFR signaling | COSMIC; PMID: 25642768 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 14.0 | Embryonic kidney; high expression |
| HeLa | 11.2 | Cervical carcinoma; moderate expression |
| HepG2 | 9.5 | Hepatocellular carcinoma; moderate expression |
| A549 | 7.8 | Lung carcinoma; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497C>T (p.Thr166Ile) | Missense | <0.1% | Unknown; rare variant in population databases |
| c.1045G>A (p.Gly349Ser) | Missense | <0.1% | Unknown; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in STAM2.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in STAM2.
Dominant Negative (DN)
No well-characterized dominant-negative mutations reported in STAM2.
View complete mutation data：
Gene Ontology (GO)
Pathways
• ESCRT-0 complex (endosomal sorting)
• EGFR downregulation
• Cytokine signaling (JAK/STAT pathway)
• Endocytosis and receptor recycling
Protein Summary
STAM2 is a 525-amino acid adaptor protein containing a VHS domain, a UIM (ubiquitin-interacting motif), and an SH3 domain. It forms a complex with HRS (HGS) to constitute the ESCRT-0 complex, which recognizes ubiquitinated cargo on endosomal membranes and facilitates sorting into multivesicular bodies for lysosomal degradation. STAM2 also interacts with JAK kinases and STAT transcription factors, modulating cytokine receptor signaling. Its expression is ubiquitous, with higher levels in testis and brain.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STAM2 Knockout HEK293 Cell Line | EDJ-KQ534 | Human | 10254 | Details Get a Quote |
| STAM2 Knockout HeLa Cell Line | EDJ-KQ18019 | Human | 10254 | Details Get a Quote |
| STAM2 Knockout A-549 Cell Line | EDJ-KQ18894 | Human | 10254 | Details Get a Quote |
| STAM2 Knockout HCT 116 Cell Line | EDJ-KQ18895 | Human | 10254 | Details Get a Quote |
