STAB2: Stabilin-2 Receptor and Hyaluronan Scavenger
A multifunctional scavenger receptor involved in hyaluronan clearance, angiogenesis, and immune regulation.
Gene Information Card
| Symbol | STAB2 |
|---|---|
| Full Name | stabilin 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q23.3 |
| NCBI Gene ID | 55576 ncbi.nlm.nih.gov/gene/55576 |
| Ensembl ID | ENSG00000139618 |
| UniProt ID | Q8WWQ8 |
| OMIM ID | 608556 |
| HGNC ID | 18627 |
| Aliases | FEEL-2, HARE, SCARH2, FEX2 |
Description
STAB2 encodes stabilin-2, a large transmembrane receptor primarily expressed in liver sinusoidal endothelial cells and lymphatic endothelial cells. It functions as a scavenger receptor for hyaluronan, chondroitin sulfate, and other ligands, mediating clearance from the circulation. STAB2 also participates in angiogenesis, cell adhesion, and immune surveillance. Alternative splicing generates multiple isoforms.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hyaluronan clearance deficiency | Loss of STAB2 function impairs hepatic hyaluronan uptake, leading to elevated serum hyaluronan levels. | OMIM #608556; NCBI Gene |
| Liver fibrosis / cirrhosis | Reduced STAB2 expression in liver sinusoidal endothelial cells correlates with impaired hyaluronan clearance and fibrosis progression. | PubMed; NCBI Gene |
| Cancer (colorectal, breast) | STAB2 overexpression in tumor-associated macrophages and endothelial cells may promote angiogenesis and metastasis. | COSMIC; PubMed |
| Atherosclerosis | STAB2-mediated uptake of modified lipoproteins in macrophages may contribute to foam cell formation. | PubMed; UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 48.2 | High |
| Spleen | 12.5 | Medium |
| Lymph node | 10.1 | Medium |
| Lung | 3.4 | Low |
| Kidney | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 0.5 | Low expression in hepatoma cell line |
| THP-1 | 8.3 | Monocyte/macrophage line; upregulated upon differentiation |
| HUVEC | 15.7 | Endothelial cells; high expression |
| MCF7 | 1.2 | Breast cancer cell line; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; truncated protein |
| c.2567A>G (p.Asn856Ser) | Missense | 0.2% | Unknown; predicted benign |
| c.3456_3457insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in STAB2 lead to truncated or absent protein, impairing hyaluronan clearance and scavenger function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in STAB2.
Dominant Negative (DN)
No evidence of dominant-negative effects for STAB2 mutations.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Hyaluronan metabolism and clearance
• Scavenger receptor pathway
• Endocytosis and vesicle trafficking
• Angiogenesis (VEGF signaling)
Protein Summary
Stabilin-2 (also known as HARE) is a 2551-amino acid transmembrane glycoprotein with multiple fasciclin, EGF-like, and laminin G domains. It binds and internalizes hyaluronan, chondroitin sulfate, and other ligands via clathrin-mediated endocytosis. The protein is critical for maintaining hyaluronan homeostasis and is implicated in liver sinusoidal endothelial cell function, lymphatic vessel integrity, and tumor angiogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STAB2 Knockout HEK293 Cell Line | EDJ-KQ11970 | Human | 55576 | Details Get a Quote |
| STAB2 Knockout HeLa Cell Line | EDJ-KQ56602 | Human | 55576 | Details Get a Quote |
| STAB2 Knockout A-549 Cell Line | EDJ-KQ65103 | Human | 55576 | Details Get a Quote |
| STAB2 Knockout HCT 116 Cell Line | EDJ-KQ73548 | Human | 55576 | Details Get a Quote |
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