STAB1: Stabilin-1 Receptor and Scavenger Protein
A multifunctional scavenger receptor involved in angiogenesis, inflammation, and tumor progression.
Gene Information Card
| Symbol | STAB1 |
|---|---|
| Full Name | Stabilin-1 |
| Gene Type | Protein coding |
| Chromosomal Location | 3p21.1 |
| NCBI Gene ID | 23166 ncbi.nlm.nih.gov/gene/23166 |
| Ensembl ID | ENSG00000114771 |
| UniProt ID | Q9NY15 |
| OMIM ID | 608560 |
| HGNC ID | 18627 |
| Aliases | FEEL-1, CLEVER-1, KIAA0246 |
Description
STAB1 encodes stabilin-1, a large transmembrane scavenger receptor expressed on sinusoidal endothelial cells and alternatively activated macrophages. It mediates endocytosis of modified low-density lipoproteins, advanced glycation end-products, and apoptotic cells. Stabilin-1 also functions in angiogenesis, leukocyte trafficking, and immune regulation. Its expression is upregulated in tumor-associated macrophages and inflamed tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | STAB1 overexpression in tumor-associated macrophages promotes angiogenesis and immune evasion. | PMID: 25636840 |
| Colorectal cancer | High STAB1 expression correlates with poor prognosis and increased metastasis. | PMID: 30348673 |
| Atherosclerosis | Stabilin-1 mediates uptake of oxidized LDL in macrophages, contributing to foam cell formation. | PMID: 19229032 |
| Rheumatoid arthritis | STAB1 expressed on synovial macrophages facilitates leukocyte adhesion and inflammation. | PMID: 21187405 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Lung | 6.1 | Low |
| Lymph node | 5.4 | Low |
| Bone marrow | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 4.8 | Hepatocellular carcinoma cell line |
| THP-1 | 7.1 | Monocytic leukemia, upregulated upon macrophage differentiation |
| U-937 | 5.9 | Histiocytic lymphoma, monocyte-like |
| A549 | 2.3 | Lung carcinoma, low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown functional impact; rare population variant |
| c.4567_4568del (p.Leu1523fs) | Frameshift | <0.01% | Predicted loss of function; no disease association reported |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Leu1523fs) are predicted to truncate the protein, impairing scavenger receptor activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported in STAB1.
Dominant Negative (DN)
No dominant-negative mutations have been described for STAB1.
View complete mutation data：
Gene Ontology (GO)
| • scavenger receptor activity (GO:0005044) | • receptor-mediated endocytosis (GO:0006898) |
| • angiogenesis (GO:0001525) | • inflammatory response (GO:0006954) |
| • plasma membrane (GO:0005886) |
Pathways
• Scavenger receptor pathway (Reactome: R-HSA-3000480)
• Endocytosis (KEGG: hsa04144)
Protein Summary
Stabilin-1 is a 2570-amino acid type I transmembrane glycoprotein with multiple fasciclin, EGF-like, and laminin-type EGF domains. It functions as a scavenger receptor for modified lipoproteins, advanced glycation end-products, and apoptotic cells. The protein is predominantly expressed on sinusoidal endothelial cells of the liver, spleen, and lymph nodes, as well as on alternatively activated macrophages. Stabilin-1 mediates cell adhesion, angiogenesis, and immune modulation, and its overexpression is linked to tumor progression and chronic inflammation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| Stab1 Knockout MB49 Cell Line | EDJ-KQ55 | Mouse | 192187 | Details Get a Quote |
| STAB1 Knockout HEK293 Cell Line | EDJ-KQ7861 | Human | 23166 | Details Get a Quote |
| STAB1 Knockout HeLa Cell Line | EDJ-KQ55698 | Human | 23166 | Details Get a Quote |
| STAB1 Knockout A-549 Cell Line | EDJ-KQ64195 | Human | 23166 | Details Get a Quote |
| STAB1 Knockout HCT 116 Cell Line | EDJ-KQ72640 | Human | 23166 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
