SSX2IP
SSX2 Interacting Protein
Gene Information Card
| Symbol | SSX2IP |
|---|---|
| Full Name | SSX2 interacting protein |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.22 |
| NCBI Gene ID | 117178 ncbi.nlm.nih.gov/gene/117178 |
| Ensembl ID | ENSG00000117155 |
| UniProt ID | Q9Y2D8 |
| OMIM ID | 608374 |
| HGNC ID | 16594 |
| Aliases | ADIP, hADIP, AF1q, MGC133155 |
Description
SSX2IP (SSX2 interacting protein) encodes a protein involved in cell adhesion and centrosome function. It interacts with the SSX2 protein and plays a role in the regulation of mitotic spindle assembly and cytokinesis. The gene is located on chromosome 1p36.22 and is expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute myeloid leukemia | Overexpression of SSX2IP disrupts normal hematopoiesis and promotes leukemogenesis | PMID: 15184675 |
| Breast cancer | Altered expression associated with tumor progression and metastasis | PMID: 21746835 |
| Hepatocellular carcinoma | Upregulation correlates with poor prognosis | PMID: 25642768 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Bone marrow | 8.7 | Medium |
| Lymph node | 6.5 | Low |
| Brain | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (leukemia) | 15.2 | High expression |
| MCF7 (breast cancer) | 9.8 | Medium expression |
| HepG2 (liver cancer) | 11.4 | Medium expression |
| HEK293 (embryonic kidney) | 5.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.214C>T | missense | <0.1% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; potential loss of centrosomal localization
Gain of Function (GOF)
Overexpression in leukemia suggests oncogenic gain-of-function
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion | • centrosome |
| • mitotic spindle organization | • protein binding |
| • cytoplasm |
Pathways
• Wnt signaling pathway
• Cell cycle - mitotic
Protein Summary
The SSX2IP protein is a 45 kDa cytoplasmic protein that localizes to centrosomes and the midbody during cell division. It interacts with SSX2 and other proteins to regulate spindle assembly and cytokinesis. Overexpression is linked to several cancers, particularly acute myeloid leukemia.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SSX2IP Knockout HEK293 Cell Line | EDJ-KQ7600 | Human | 117178 | Details Get a Quote |
| SSX2IP Knockout A-549 Cell Line | EDJ-KQ32940 | Human | 117178 | Details Get a Quote |
| SSX2IP Knockout HCT 116 Cell Line | EDJ-KQ32941 | Human | 117178 | Details Get a Quote |
| SSX2IP Knockout HeLa Cell Line | EDJ-KQ32942 | Human | 117178 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
