SSU72L6 Gene: SSU72 Like RNA Polymerase II CTD Phosphatase Subunit 6
A pseudogene-derived transcript with limited functional annotation, located on chromosome 1, implicated in potential regulatory roles.
Gene Information Card
| Symbol | SSU72L6 |
|---|---|
| Full Name | SSU72 like RNA polymerase II CTD phosphatase subunit 6 |
| Gene Type | protein-coding (putative) |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 100130776 ncbi.nlm.nih.gov/gene/100130776 |
| Ensembl ID | ENSG00000284662 |
| UniProt ID | A0A1B0GTV4 |
| OMIM ID | None |
| HGNC ID | HGNC:44225 |
| Aliases | SSU72L, SSU72 like 6 |
Description
SSU72L6 is a gene located on the short arm of chromosome 1 (1p36.33). It is predicted to encode a protein similar to SSU72, a phosphatase involved in RNA polymerase II transcription regulation. However, SSU72L6 is considered a putative protein-coding gene with limited experimental validation. It may be a processed pseudogene or a transcribed pseudogene with potential regulatory functions. Expression data suggest low to moderate activity in certain tissues, but its biological role remains largely uncharacterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No direct disease association | Not established | No curated disease links in OMIM or ClinVar as of 2025 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Thyroid | 3.1 | Low |
| Adrenal gland | 2.8 | Low |
| Other tissues | Not detected | Not expressed |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.0 | Not expressed |
| K562 | 0.0 | Not expressed |
| HUVEC | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | N/A | N/A | No functional impact data |
Mutation functional classification
Loss of Function (LOF)
No evidence
Gain of Function (GOF)
No evidence
Dominant Negative (DN)
No evidence
View complete mutation data：
Gene Ontology (GO)
| • Molecular function: phosphoprotein phosphatase activity (predicted) | • Biological process: transcription regulation (predicted) |
Pathways
• RNA polymerase II transcription (inferred from SSU72 homology)
Protein Summary
The SSU72L6 protein is predicted to be a small protein with similarity to SSU72, a CTD phosphatase. However, its expression at the protein level has not been confirmed. It may lack catalytic activity due to mutations in key residues. The protein is likely localized to the nucleus if expressed, but experimental data are absent.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SSU72L6 Knockout HEK293 Cell Line | EDJ-KQ15523 | Human | 136157 | Details Get a Quote |
| SSU72L6 Knockout A-549 Cell Line | EDJ-KQ46354 | Human | 136157 | Details Get a Quote |
| SSU72L6 Knockout HCT 116 Cell Line | EDJ-KQ46355 | Human | 136157 | Details Get a Quote |
| SSU72L6 Knockout HeLa Cell Line | EDJ-KQ46356 | Human | 136157 | Details Get a Quote |
