SSTR4 (Somatostatin Receptor 4)
A G protein-coupled receptor for somatostatin with roles in neuroendocrine signaling and potential therapeutic targeting
Gene Information Card
| Symbol | SSTR4 |
|---|---|
| Full Name | Somatostatin Receptor 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 20p11.21 |
| NCBI Gene ID | 6754 ncbi.nlm.nih.gov/gene/6754 |
| Ensembl ID | ENSG00000132671 |
| UniProt ID | P31391 |
| OMIM ID | 182454 |
| HGNC ID | 11333 |
| Aliases | SS4R, somatostatin receptor subtype 4 |
Description
SSTR4 encodes somatostatin receptor 4, a member of the G protein-coupled receptor family that binds somatostatin and cortistatin. The receptor is involved in inhibition of adenylyl cyclase, modulation of ion channels, and regulation of cell proliferation. SSTR4 is expressed in brain, pancreas, and immune cells, and has been implicated in neuroendocrine signaling, pain modulation, and cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuroendocrine tumors | SSTR4 overexpression may mediate antiproliferative effects via somatostatin analog binding; used in imaging and therapy | PMID: 25670057 |
| Alzheimer disease | Reduced SSTR4 expression in hippocampus may contribute to cognitive decline | PMID: 17984056 |
| Inflammatory pain | SSTR4 activation in sensory neurons reduces nociception in animal models | PMID: 22171089 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain (cerebral cortex) | 12.5 | Medium |
| Pancreas | 8.3 | Low |
| Adrenal gland | 6.1 | Low |
| Spleen | 4.7 | Low |
| Lung | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | Neuronal model |
| HEK293 (embryonic kidney) | 0.8 | Low endogenous expression |
| MIA PaCa-2 (pancreatic cancer) | 5.6 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.776G>A (p.Arg259His) | Missense | <0.01% | Altered ligand binding affinity (in vitro) |
| c.1042C>T (p.Pro348Ser) | Missense | <0.01% | Reduced cell surface expression |
Mutation functional classification
Loss of Function (LOF)
p.Pro348Ser reduces receptor trafficking to plasma membrane
Gain of Function (GOF)
No confirmed gain-of-function variants reported
Dominant Negative (DN)
Not described for SSTR4
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • somatostatin receptor activity |
| • adenylate cyclase inhibiting pathway | • negative regulation of cell population proliferation |
| • neuropeptide signaling pathway |
Pathways
• Somatostatin receptor signaling (Reactome: R-HSA-418594)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
Somatostatin receptor 4 is a 388-amino acid integral membrane protein with seven transmembrane domains. It couples primarily to Gi/o proteins, inhibiting adenylyl cyclase and reducing cAMP levels. The receptor is a target for synthetic somatostatin analogs used in neuroendocrine tumor imaging and therapy.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SSTR4 Knockout HEK293 Cell Line | EDJ-KQ5849 | Human | 6754 | Details Get a Quote |
| SSTR4 Knockout HeLa Cell Line | EDJ-KQ54573 | Human | 6754 | Details Get a Quote |
| SSTR4 Knockout A-549 Cell Line | EDJ-KQ63058 | Human | 6754 | Details Get a Quote |
| SSTR4 Knockout HCT 116 Cell Line | EDJ-KQ71532 | Human | 6754 | Details Get a Quote |
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