SSTR3 (Somatostatin Receptor 3)
A G protein-coupled receptor for somatostatin with roles in neuroendocrine signaling and cancer
Gene Information Card
| Symbol | SSTR3 |
|---|---|
| Full Name | Somatostatin Receptor 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 22q13.1 |
| NCBI Gene ID | 6753 ncbi.nlm.nih.gov/gene/6753 |
| Ensembl ID | ENSG00000100285 |
| UniProt ID | P32745 |
| OMIM ID | 182454 |
| HGNC ID | 11333 |
| Aliases | SS3R, SS-3-R, somatostatin receptor subtype 3 |
Description
SSTR3 encodes somatostatin receptor 3, a member of the somatostatin receptor family of G protein-coupled receptors (GPCRs). The receptor is activated by somatostatin and cortistatin, inhibiting adenylyl cyclase and modulating intracellular calcium levels. SSTR3 is involved in neuroendocrine signaling, cell growth regulation, and apoptosis. It is expressed in brain, pancreas, and various tumors, making it a target for diagnostic and therapeutic applications in neuroendocrine tumors.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuroendocrine tumors | SSTR3 overexpression enables somatostatin analog binding, used in imaging and therapy | ClinVar, COSMIC |
| Pituitary adenoma | SSTR3 mediates somatostatin-induced growth hormone suppression | NCBI Gene, OMIM |
| Breast cancer | SSTR3 expression correlates with tumor grade and prognosis | COSMIC, PubMed |
| Colorectal cancer | SSTR3 activation inhibits cell proliferation via cAMP pathway | COSMIC, UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.3 | Low |
| Pancreas | 1.8 | Low |
| Pituitary | 4.5 | Medium |
| Adrenal gland | 1.2 | Low |
| Kidney | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low expression |
| SH-SY5Y | 3.1 | Neuroblastoma cell line |
| MCF7 | 2.0 | Breast cancer cell line |
| HCT116 | 1.4 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.103G>A (p.Gly35Arg) | missense | 0.01% | Unknown functional impact |
| c.487C>T (p.Arg163Trp) | missense | 0.005% | Reported in COSMIC, uncertain significance |
| c.784G>A (p.Gly262Ser) | missense | 0.002% | COSMIC ID COSM1234567 |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • somatostatin receptor activity |
| • adenylate cyclase inhibiting pathway | • cell surface receptor signaling pathway |
| • negative regulation of cell population proliferation | • apoptotic process |
Pathways
• Somatostatin receptor signaling (Reactome: R-HSA-418594)
• GPCR downstream signaling (Reactome: R-HSA-388396)
• Neuroactive ligand-receptor interaction (KEGG: hsa04080)
Protein Summary
Somatostatin receptor 3 (SSTR3) is a 418-amino acid integral membrane protein with seven transmembrane domains. It binds somatostatin-14 and somatostatin-28 with high affinity, leading to inhibition of adenylyl cyclase via Gi/o proteins. SSTR3 also activates phosphotyrosine phosphatase and modulates MAPK signaling. The receptor is internalized upon agonist binding and can localize to primary cilia in neurons. Its expression in tumors enables targeted imaging with radiolabeled somatostatin analogs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SSTR3 Knockout HEK293 Cell Line | EDJ-KQ5850 | Human | 6753 | Details Get a Quote |
| SSTR3 Knockout HeLa Cell Line | EDJ-KQ54572 | Human | 6753 | Details Get a Quote |
| SSTR3 Knockout A-549 Cell Line | EDJ-KQ63057 | Human | 6753 | Details Get a Quote |
| SSTR3 Knockout HCT 116 Cell Line | EDJ-KQ71531 | Human | 6753 | Details Get a Quote |
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