SSTR2 (Somatostatin Receptor 2)
A key G protein-coupled receptor mediating somatostatin signaling in neuroendocrine regulation and oncology.
Gene Information Card
| Symbol | SSTR2 |
|---|---|
| Full Name | Somatostatin Receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q25.1 |
| NCBI Gene ID | 6752 ncbi.nlm.nih.gov/gene/6752 |
| Ensembl ID | ENSG00000180616 |
| UniProt ID | P30874 |
| OMIM ID | 182452 |
| HGNC ID | 11332 |
| Aliases | SS2R, SRIF-1 |
Description
SSTR2 encodes somatostatin receptor 2, a G protein-coupled receptor for somatostatin-14 and -28. It mediates inhibition of hormone secretion, cell proliferation, and induces apoptosis. SSTR2 is highly expressed in neuroendocrine tissues and is a primary target for diagnostic imaging and peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumors.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuroendocrine tumors (NETs) | SSTR2 overexpression enables targeted imaging and therapy via somatostatin analogs | PMID: 31383879 |
| Acromegaly | SSTR2 mediates somatostatin-induced suppression of GH secretion; loss of SSTR2 correlates with resistance to somatostatin analogs | PMID: 25636053 |
| Gastroenteropancreatic NETs | SSTR2 expression is a predictive biomarker for response to octreotide and lanreotide | PMID: 28854169 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 12.3 | Medium |
| Pituitary | 8.7 | Medium |
| Brain (cortex) | 6.1 | Low |
| Stomach | 15.2 | High |
| Small intestine | 18.9 | High |
| Colon | 4.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| BON-1 (pancreatic NET) | 22.1 | High SSTR2 expression |
| QGP-1 (pancreatic NET) | 18.7 | High SSTR2 expression |
| NCI-H727 (lung carcinoid) | 14.3 | Moderate SSTR2 expression |
| HEK293 | 0.8 | Very low endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.784G>A (p.Gly262Ser) | Missense | <0.1% | Reduced ligand binding affinity |
| c.1019C>T (p.Thr340Met) | Missense | <0.1% | Impaired receptor internalization |
| c.1123_1125del (p.Phe375del) | In-frame deletion | <0.1% | Loss of G protein coupling |
Mutation functional classification
Loss of Function (LOF)
Mutations such as p.Phe375del impair G protein coupling and signal transduction, reducing somatostatin-mediated inhibition.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in SSTR2.
Dominant Negative (DN)
No dominant-negative mutations described for SSTR2.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity (GO:0004930) | • somatostatin receptor activity (GO:0004994) |
| • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (GO:0007193) | • negative regulation of cell population proliferation (GO:0008285) |
| • apoptotic process (GO:0006915) |
Pathways
• Somatostatin signaling (Reactome: R-HSA-418594)
• GPCR downstream signaling (Reactome: R-HSA-388396)
• Peptide ligand-binding receptors (Reactome: R-HSA-375276)
Protein Summary
Somatostatin receptor 2 (SSTR2) is a 369-amino acid transmembrane GPCR that preferentially binds somatostatin-14 and -28. Upon activation, it couples to Gi/o proteins to inhibit adenylyl cyclase, reduce cAMP, and modulate ion channels. SSTR2 is a key mediator of somatostatin's anti-secretory and anti-proliferative effects, and its overexpression in neuroendocrine tumors is exploited clinically for imaging (68Ga-DOTATATE PET) and therapy (177Lu-DOTATATE PRRT).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SSTR2 Knockout HEK293 Cell Line | EDJ-KQ1791 | Human | 6752 | Details Get a Quote |
| SSTR2 Knockout HeLa Cell Line | EDJ-KQ54571 | Human | 6752 | Details Get a Quote |
| SSTR2 Knockout A-549 Cell Line | EDJ-KQ63056 | Human | 6752 | Details Get a Quote |
| SSTR2 Knockout HCT 116 Cell Line | EDJ-KQ71530 | Human | 6752 | Details Get a Quote |
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