SSTR1: Somatostatin Receptor 1
A comprehensive guide to SSTR1 gene, its function, expression, and clinical significance.
Gene Information Card
| Symbol | SSTR1 |
|---|---|
| Full Name | Somatostatin Receptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q21.1 |
| NCBI Gene ID | 6751 ncbi.nlm.nih.gov/gene/6751 |
| Ensembl ID | ENSG00000139874 |
| UniProt ID | P30872 |
| OMIM ID | 182451 |
| HGNC ID | 11330 |
| Aliases | SRIF-2, SS-1-R, SS1R |
Description
SSTR1 (Somatostatin Receptor 1) is a protein-coding gene that encodes a G protein-coupled receptor for somatostatin. This receptor is involved in inhibiting cell proliferation, regulating hormone secretion, and modulating neurotransmission. It is widely expressed in the brain, pancreas, and gastrointestinal tract.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neuroendocrine tumors | SSTR1 overexpression in tumors allows targeted imaging and therapy via somatostatin analogs. | PMID: 25670806 |
| Acromegaly | SSTR1 activation inhibits growth hormone secretion from pituitary adenomas. | PMID: 16968795 |
| Alzheimer's disease | Reduced SSTR1 expression in the hippocampus may contribute to cognitive decline. | PMID: 21867890 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Pancreas | 8.3 | Medium |
| Stomach | 6.1 | Low |
| Small intestine | 5.4 | Low |
| Kidney | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 10.1 | Neuroblastoma cell line |
| HEK293 | 2.5 | Low expression |
| MIA PaCa-2 | 7.8 | Pancreatic cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.103G>A (p.Gly35Arg) | Missense | <0.01% | Unknown functional effect |
| c.776C>T (p.Pro259Leu) | Missense | <0.01% | Potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in transmembrane domains may impair receptor signaling.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • somatostatin receptor activity |
| • negative regulation of cell proliferation | • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| • neuropeptide signaling pathway |
Pathways
• Somatostatin receptor signaling
• GPCR downstream signaling
• cAMP inhibition pathway
Protein Summary
SSTR1 is a 391-amino acid integral membrane protein with seven transmembrane domains. It binds somatostatin with high affinity and couples to Gi/o proteins, inhibiting adenylate cyclase and reducing cAMP levels. This receptor mediates antiproliferative and antisecretory effects in various tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SSTR1 Knockout HEK293 Cell Line | EDJ-KQ1790 | Human | 6751 | Details Get a Quote |
| SSTR1 Knockout HeLa Cell Line | EDJ-KQ20318 | Human | 6751 | Details Get a Quote |
| SSTR1 Knockout A-549 Cell Line | EDJ-KQ63055 | Human | 6751 | Details Get a Quote |
| SSTR1 Knockout HCT 116 Cell Line | EDJ-KQ71529 | Human | 6751 | Details Get a Quote |
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