SRPRA Gene - Signal Recognition Particle Receptor Subunit Alpha
Comprehensive genomic and proteomic analysis of SRPRA, a key component of the signal recognition particle receptor complex involved in protein targeting to the endoplasmic reticulum.
Gene Information Card
| Symbol | SRPRA |
|---|---|
| Full Name | Signal Recognition Particle Receptor Subunit Alpha |
| Gene Type | Protein coding |
| Chromosomal Location | 11q24.2 |
| NCBI Gene ID | 6734 ncbi.nlm.nih.gov/gene/6734 |
| Ensembl ID | ENSG00000110367 |
| UniProt ID | P08240 |
| OMIM ID | 182180 |
| HGNC ID | 11308 |
| Aliases | SR-alpha, SRP alpha, SRPR |
Description
The SRPRA gene encodes the alpha subunit of the signal recognition particle (SRP) receptor, a transmembrane protein localized to the endoplasmic reticulum (ER). The SRP receptor, together with the SRP, mediates the targeting of nascent secretory and membrane proteins to the ER membrane. The alpha subunit contains a GTPase domain essential for SRP binding and GTP-dependent protein translocation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Pancreas | 10.8 | Medium |
| Kidney | 9.2 | Medium |
| Heart | 7.6 | Low |
| Brain | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.3 | Hepatocellular carcinoma cell line |
| HeLa | 11.0 | Cervical adenocarcinoma cell line |
| K562 | 8.5 | Chronic myeloid leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | No known functional effect |
| c.100C>T | Synonymous | <0.01% | No known functional effect |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • GTPase activity | • GTP binding |
| • signal recognition particle receptor activity | • protein targeting to ER |
| • endoplasmic reticulum membrane |
Pathways
• Signal recognition particle (SRP)-dependent cotranslational protein targeting to membrane
• Protein processing in endoplasmic reticulum
Protein Summary
The SRP receptor alpha subunit (SRPRA) is a 638-amino acid transmembrane protein with a cytosolic GTPase domain. It forms a heterodimer with the beta subunit (SRPRB) to constitute the functional SRP receptor. Upon binding of the SRP-ribosome-nascent chain complex, SRPRA undergoes GTP hydrolysis to release the ribosome to the ER translocon, facilitating cotranslational translocation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SRPRA Knockout HEK293 Cell Line | EDJ-KQ5092 | Human | 6734 | Details Get a Quote |
| SRPRA Knockout A-549 Cell Line | EDJ-KQ29297 | Human | 6734 | Details Get a Quote |
| SRPRA Knockout HCT 116 Cell Line | EDJ-KQ29298 | Human | 6734 | Details Get a Quote |
| SRPRA Knockout HeLa Cell Line | EDJ-KQ29299 | Human | 6734 | Details Get a Quote |
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