SRP9: Signal Recognition Particle 9
A key component of the signal recognition particle complex involved in co-translational protein targeting to the endoplasmic reticulum.
Gene Information Card
| Symbol | SRP9 |
|---|---|
| Full Name | Signal Recognition Particle 9 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q42.12 |
| NCBI Gene ID | 6726 ncbi.nlm.nih.gov/gene/6726 |
| Ensembl ID | ENSG00000143742 |
| UniProt ID | P49458 |
| OMIM ID | 604707 |
| HGNC ID | 11302 |
| Aliases | SRP9, SRP9P, SRP9L |
Description
The SRP9 gene encodes the 9 kDa subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that targets nascent secretory and membrane proteins to the endoplasmic reticulum (ER) for co-translational translocation. SRP9, together with SRP14, forms the Alu domain of the SRP, which is responsible for the elongation arrest function of the SRP. This function pauses translation until the ribosome-SRP complex docks with the SRP receptor on the ER membrane.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Liver | 10.3 | Medium |
| Kidney | 9.8 | Medium |
| Heart | 8.7 | Low |
| Lung | 7.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.2 | High expression |
| HeLa | 12.1 | Medium expression |
| K562 | 9.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in human disease.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
No documented dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
Pathways
• SRP-dependent cotranslational protein targeting to membrane (Reactome: R-HSA-1799339)
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
Protein Summary
SRP9 is a small, basic protein that forms a heterodimer with SRP14. This heterodimer binds to the 7SL RNA component of the SRP, forming the Alu domain. The Alu domain is essential for the elongation arrest activity of the SRP, which ensures that translation is paused until the ribosome-SRP complex is properly targeted to the ER membrane. SRP9 is ubiquitously expressed and is highly conserved across eukaryotes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SRP9 Knockout HEK293 Cell Line | EDJ-KQ50657 | Human | 6726 | Details Get a Quote |
| SRP9 Knockout HeLa Cell Line | EDJ-KQ54564 | Human | 6726 | Details Get a Quote |
| SRP9 Knockout A-549 Cell Line | EDJ-KQ63048 | Human | 6726 | Details Get a Quote |
| SRP9 Knockout HCT 116 Cell Line | EDJ-KQ71522 | Human | 6726 | Details Get a Quote |
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