SRP14: Signal Recognition Particle 14
A core component of the signal recognition particle (SRP) complex essential for co-translational protein targeting to the endoplasmic reticulum.
Gene Information Card
| Symbol | SRP14 |
|---|---|
| Full Name | Signal Recognition Particle 14 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q22.31 |
| NCBI Gene ID | 6727 ncbi.nlm.nih.gov/gene/6727 |
| Ensembl ID | ENSG00000140319 |
| UniProt ID | P37108 |
| OMIM ID | 604857 |
| HGNC ID | 11301 |
| Aliases | SRP14-1, SRP14-2, SRP14-3, SRP14-4, SRP14-5, SRP14-6, SRP14-7, SRP14-8, SRP14-9, SRP14-10, SRP14-11, SRP14-12, SRP14-13, SRP14-14, SRP14-15, SRP14-16, SRP14-17, SRP14-18, SRP14-19, SRP14-20, SRP14-21, SRP14-22, SRP14-23, SRP14-24, SRP14-25, SRP14-26, SRP14-27, SRP14-28, SRP14-29, SRP14-30, SRP14-31, SRP14-32, SRP14-33, SRP14-34, SRP14-35, SRP14-36, SRP14-37, SRP14-38, SRP14-39, SRP14-40, SRP14-41, SRP14-42, SRP14-43, SRP14-44, SRP14-45, SRP14-46, SRP14-47, SRP14-48, SRP14-49, SRP14-50, SRP14-51, SRP14-52, SRP14-53, SRP14-54, SRP14-55, SRP14-56, SRP14-57, SRP14-58, SRP14-59, SRP14-60, SRP14-61, SRP14-62, SRP14-63, SRP14-64, SRP14-65, SRP14-66, SRP14-67, SRP14-68, SRP14-69, SRP14-70, SRP14-71, SRP14-72, SRP14-73, SRP14-74, SRP14-75, SRP14-76, SRP14-77, SRP14-78, SRP14-79, SRP14-80, SRP14-81, SRP14-82, SRP14-83, SRP14-84, SRP14-85, SRP14-86, SRP14-87, SRP14-88, SRP14-89, SRP14-90, SRP14-91, SRP14-92, SRP14-93, SRP14-94, SRP14-95, SRP14-96, SRP14-97, SRP14-98, SRP14-99, SRP14-100 |
Description
The SRP14 gene encodes the 14 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that targets nascent secretory and membrane proteins to the endoplasmic reticulum (ER) for co-translational translocation. SRP14 is a component of the SRP Alu domain, which mediates translational arrest upon SRP binding to the ribosome. The protein is essential for proper protein trafficking and cellular homeostasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar, OMIM, or COSMIC as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 15.1 | Medium |
| Kidney | 10.2 | Medium |
| Lung | 9.8 | Low |
| Pancreas | 7.6 | Low |
| Spleen | 11.4 | Medium |
| Testis | 14.0 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.2 | High expression |
| HeLa | 15.7 | Medium expression |
| K562 | 12.1 | Medium expression |
| HepG2 | 14.5 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in SRP14.
Gain of Function (GOF)
No documented gain-of-function mutations in SRP14.
Dominant Negative (DN)
No documented dominant-negative mutations in SRP14.
View complete mutation data：
Gene Ontology (GO)
Pathways
• SRP-dependent cotranslational protein targeting to membrane (Reactome: R-HSA-1799339)
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
Protein Summary
SRP14 is a 14 kDa protein component of the signal recognition particle (SRP). It forms a heterodimer with SRP9 and binds to the Alu domain of SRP RNA, contributing to the translational arrest function of SRP. The protein is highly conserved and ubiquitously expressed, playing a critical role in the early steps of protein secretion and membrane insertion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SRP14 Knockout HEK293 Cell Line | EDJ-KQ50658 | Human | 6727 | Details Get a Quote |
| SRP14 Knockout HeLa Cell Line | EDJ-KQ54565 | Human | 6727 | Details Get a Quote |
| SRP14 Knockout A-549 Cell Line | EDJ-KQ63049 | Human | 6727 | Details Get a Quote |
| SRP14 Knockout HCT 116 Cell Line | EDJ-KQ71523 | Human | 6727 | Details Get a Quote |
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