SRMS: Src-Related Kinase Lacking C-Terminal Regulatory Tyrosine and N-Terminal Myristoylation Sites
A non-receptor tyrosine kinase of the Src family with unique structural features and tissue-specific expression.
Gene Information Card
| Symbol | SRMS |
|---|---|
| Full Name | Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.33 |
| NCBI Gene ID | 6725 ncbi.nlm.nih.gov/gene/6725 |
| Ensembl ID | ENSG00000101204 |
| UniProt ID | Q9H3Y6 |
| OMIM ID | 611199 |
| HGNC ID | 11299 |
| Aliases | SRM, SRC-related kinase, SRC-like kinase |
Description
SRMS (Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites) is a protein-coding gene that encodes a non-receptor tyrosine kinase belonging to the Src family. Unlike canonical Src kinases, SRMS lacks both the N-terminal myristoylation signal and the C-terminal regulatory tyrosine residue, suggesting distinct regulatory mechanisms. The protein is involved in cell signaling and proliferation, with expression predominantly in testis and certain cancer cell lines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | SRMS overexpression may contribute to oncogenic signaling via aberrant kinase activity. | COSMIC; limited direct evidence |
| Testicular germ cell tumors | Elevated SRMS expression in testis suggests potential role in testicular cancer pathogenesis. | NCBI Gene; expression data |
| Breast cancer | SRMS has been reported as a potential biomarker in breast cancer subtypes. | COSMIC; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Fallopian tube | 4.2 | Low |
| Prostate | 3.8 | Low |
| Thyroid | 3.1 | Low |
| Adrenal gland | 2.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | Highest expression in this cell line |
| K-562 | 8.7 | Moderate expression |
| HeLa | 6.2 | Moderate expression |
| A549 | 4.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Ile) | Missense | <0.01% | Unknown; likely benign |
| c.452G>A (p.Arg151His) | Missense | <0.01% | Unknown; likely benign |
| c.784C>T (p.Arg262Trp) | Missense | <0.01% | Unknown; likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in SRMS.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in SRMS.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in SRMS.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004715 (GO:0004715) | • GO:0005524 (GO:0005524) |
| • GO:0006468 (GO:0006468) | • GO:0018108 (GO:0018108) |
| • GO:0046777 (GO:0046777) |
Pathways
• Signal Transduction (Reactome: R-HSA-162582)
• Signaling by Receptor Tyrosine Kinases (Reactome: R-HSA-9006934)
Protein Summary
The SRMS protein (UniProt Q9H3Y6) is a 488-amino acid non-receptor tyrosine kinase. It contains an SH3 domain, an SH2 domain, and a tyrosine kinase catalytic domain, but lacks the N-terminal myristoylation site and C-terminal regulatory tyrosine typical of Src family kinases. This unique structure suggests alternative membrane localization and regulation. The protein is predominantly cytoplasmic and may be involved in cell proliferation and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SRMS Knockout HEK293 Cell Line | EDJ-KQ5853 | Human | 6725 | Details Get a Quote |
| SRMS Knockout HCT 116 Cell Line | EDJ-KQ29322 | Human | 6725 | Details Get a Quote |
| SRMS Knockout HeLa Cell Line | EDJ-KQ54563 | Human | 6725 | Details Get a Quote |
| SRMS Knockout A-549 Cell Line | EDJ-KQ63047 | Human | 6725 | Details Get a Quote |
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