SRCIN1
SRC Kinase Signaling Inhibitor 1
Gene Information Card
| Symbol | SRCIN1 |
|---|---|
| Full Name | SRC Kinase Signaling Inhibitor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 80762 ncbi.nlm.nih.gov/gene/80762 |
| Ensembl ID | ENSG00000141510 |
| UniProt ID | Q9H0Y0 |
| OMIM ID | 611625 |
| HGNC ID | 29518 |
| Aliases | p140Cap, SNIP |
Description
SRCIN1 encodes a protein that functions as a negative regulator of SRC kinase signaling. It is involved in cytoskeletal organization, cell adhesion, and migration. The protein is a scaffold that recruits signaling molecules and modulates pathways such as MAPK and PI3K/AKT. SRCIN1 is considered a tumor suppressor in several cancers, including breast and lung cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Loss of SRCIN1 expression leads to increased SRC activity and enhanced cell migration/invasion | PMID: 20526336 |
| Lung Cancer | Reduced SRCIN1 expression correlates with poor prognosis and increased metastasis | PMID: 23382223 |
| Colorectal Cancer | SRCIN1 downregulation promotes tumor growth via SRC/FAK signaling | PMID: 25605247 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Breast | 6.7 | Low |
| Colon | 5.9 | Low |
| Kidney | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 6.1 | Low expression |
| A549 (lung cancer) | 4.8 | Low expression |
| HEK293 (embryonic kidney) | 9.2 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function |
| c.567_568del (p.Glu190fs) | Frameshift | <0.1% | Loss of function |
| c.890A>G (p.Asn297Ser) | Missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations lead to truncated protein and loss of SRC inhibitory activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• SRC signaling pathway
• MAPK signaling pathway
• PI3K/AKT signaling pathway
• Focal adhesion
Protein Summary
SRCIN1 (p140Cap) is a 140 kDa scaffold protein that localizes to the cytoplasm and cytoskeleton. It binds to SRC kinase and inhibits its activity, thereby regulating cell adhesion, migration, and proliferation. The protein contains multiple proline-rich regions and a coiled-coil domain. Loss of SRCIN1 is associated with increased SRC signaling and tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SRCIN1 Knockout HEK293 Cell Line | EDJ-KQ9557 | Human | 80725 | Details Get a Quote |
| SRCIN1 Knockout A-549 Cell Line | EDJ-KQ35097 | Human | 80725 | Details Get a Quote |
| SRCIN1 Knockout HCT 116 Cell Line | EDJ-KQ36353 | Human | 80725 | Details Get a Quote |
| SRCIN1 Knockout HeLa Cell Line | EDJ-KQ36354 | Human | 80725 | Details Get a Quote |
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